|(4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-(2S,3R,4S,5S,6R)-3,4,5-三羟基-6-((((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基 9-(羟甲基)-2,2,6a,6b,9,12a-六甲基-10-(((2S,3R,4S,5S)-3,4,5-三羟基四氢-2H-吡喃-2-基)氧基)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-二十氢芘-4a-甲酸酯|CsnPharm

CAS No.: 39524-08-8

Akebia saponin D/川续断皂苷VI Catalog No. CSN15575

Synonyms: Akebia Saponin D;ASA VI;Leiyemudanoside A

Asperosaponin VI, a natural product isolated and purified from the root of Dipsacus asperoides, may exert apoptosis-inducing activity via induction of apoptosis through activation chiefly via the nitric oxide and apoptosis-related p53 and Bax gene expression.

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技术信息

生物活性

描述Asperosaponin VI (ASA VI), a saponin component from Dipsacus asper wall. ASA VI exhibited a significant induction of proliferation, differentiation and mineralization in MC3T3-E1 and primary osteoblastic cells. ASA VI may induce differentiation by increasing the activity of p38 and ERK1/2^[3]. ASA VI significantly attenuated increased LDH (lactate dehydrogenase) and CK (creatine phosphokinase) activities, and increased cell viability in hypoxia treated myocytes in a dose-dependent fashion. ASA VI treatment inhibited apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB( cAMP response element-binding protein)^[4]. ASA VI promoted the proliferation of OVX rBMSCs and enhanced ALP activity and calcified nodule formation. ASA VI promotes the osteogenic differentiation of OVX rBMSCs (osteogenic differentiation of bone marrow stromal cells) by acting on the phosphatidylinositol-3 kinase/AKT signaling pathway^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.0763 mL
- 5.3816 mL
- 10.7632 mL
- 5 mM
- 0.2153 mL
- 1.0763 mL
- 2.1526 mL
- 10 mM
- 0.1076 mL
- 0.5382 mL
- 1.0763 mL

技术信息

CAS号

39524-08-8

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C47H76O18

运输

蓝冰

分子量

929.10

别名

Akebia Saponin D;ASA VI;Leiyemudanoside A;Tauroside St-G0-1;川续断皂苷 VI;川续断皂苷Ⅵ

溶解度

DMSO	95.0 mg/mL (102.2 mM) warming

动物实验配方

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Akebia saponin D/川续断皂苷VI Catalog No. CSN15575

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