|泽泻醇B|CsnPharm

CAS No.: 18649-93-9

Alisol B/泽泻醇B Catalog No. CSN13557

Synonyms: 16-Deoxoalisol C;泽泻醇 B

Alisol B is a natural product isolated and purified from the tubers of Alisma plantago-aquatica Linn. for bone disorders by targeting the differentiation of osteoclasts as well as their functions.

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技术信息

生物活性

描述Alisol-B, a phyto-steroid from Alisma orientale Juzepczuk, exhibited inhibitory effects on osteoclastogenesis both in vitro and in vivo. Addition of alisol-B to co-cultures of mouse bone marrow cells and primary osteoblasts with 10(-8)M Alisol B caused significant inhibition of osteoclastogenesis. Alisol-B strongly inhibited RANKL-induced osteoclast formation when added during the early stage of cultures, suggesting that alisol-B acts on osteoclast precursors to inhibit RANKL/RANK signaling. In addition, alisol-B suppressed the pit-forming activity and disrupted the actin ring formation of mature osteoclasts^[3]. Alisol B-treated cells displayed an increase of autophagic flux and formation of autophagosomes, leading to cell cycle arrest at the G(1) phase and cell death. Alisol B induced calcium mobilization from internal stores, leading to autophagy through the activation of the CaMKK-AMPK-mammalian target of rapamycin pathway. Moreover, the disruption of calcium homeostasis induces endoplasmic reticulum stress and unfolded protein responses in alisol B-treated cells, leading to apoptotic cell death^[4].
参考文献

[1] Lee JW, Kobayashi Y, et al. Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice. Biochem Pharmacol. 2010 Aug 1;80(3):352-61.
[2] Law BY, Wang M, et al. Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol Cancer Ther. 2010 Mar;9(3):718-30.
[3] Lee JW, Kobayashi Y, Nakamichi Y, Udagawa N, Takahashi N, Im NK, Seo HJ, Jeon WB, Yonezawa T, Cha BY, Woo JT. Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice. Biochem Pharmacol. 2010 Aug 1;80(3):352-61
[4] Law BY, Wang M, Ma DL, Al-Mousa F, Michelangeli F, Cheng SH, Ng MH, To KF, Mok AY, Ko RY, Lam SK, Chen F, Che CM, Chiu P, Ko BC. Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol Cancer Ther. 2010 Mar;9(3):718-30

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1155 mL
- 10.5775 mL
- 21.1551 mL
- 5 mM
- 0.4231 mL
- 2.1155 mL
- 4.2310 mL
- 10 mM
- 0.2116 mL
- 1.0578 mL
- 2.1155 mL

技术信息

CAS号

18649-93-9

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H48O4

运输

蓝冰

分子量

472.70

别名

16-Deoxoalisol C;泽泻醇 B

溶解度

DMSO	95.0 mg/mL (201.0 mM)

动物实验配方

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Alisol B/泽泻醇B Catalog No. CSN13557

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