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CAS No.: 59338-87-3

Alizapride HCl/盐酸阿立必利 Catalog No. CSN10243

Synonyms: Alizapride (hydrochloride);Alizapride;59338-93-1

Alizapride HCl is a dopamine receptor antagonist used in the administration of nausea and vomiting.

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技术信息

生物活性

描述Alizapride (Hydrochloride) is a potent antiemetic, acting as a dopamine receptor antagonist on the chemoreceptor trigger zone with few gastrokinetic properties. Alizapride can be proposed as an antiemetic in patients with biliary disorders^[3]. Alizapride (Hydrochloride) is a methoxy-2-benzamide derivative three times more potent than its parent compound, metoclopramide, as an antagonist of apomorphine-induced emesis in dogs. Alizapride is more active than placebo when combined with DXM (dexamethasone) for DDP-induced (cisplatin) emesis in patients at high risk of severe nausea and vomiting^[4]. In early clinical trials alizapride showed a better antiemetic activity with fewer side effects than metoclopramide. Alizapride has antiemetic activity and few side effects in the dose of 4 mg/kg x 5^[5]. The incidence of nausea and vomiting was lower with the alizapride-treated patients, while, contrary to the experience with other antiemetics, prolonged recovery was not observed. Alizapride 100 to 200 mg intravenously is efficacious in the prevention of postoperative nausea and vomiting^[6].
临床研究

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NCT02704182	Knee Replacement	Not Applicable	Completed	-	-
NCT03178708	Spinal Curvatures	Phase 2 Phase 3	Recruiting	October 30, 2018	Egypt ... more >> Assiut governorate Recruiting Assiut, Egypt Contact: Ghada M Aboelfadl, MD 01005802086 ghadafadl77@gmail.com Collapse <<
NCT01636947	-	-	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8423 mL
- 14.2114 mL
- 28.4227 mL
- 5 mM
- 0.5685 mL
- 2.8423 mL
- 5.6845 mL
- 10 mM
- 0.2842 mL
- 1.4211 mL
- 2.8423 mL

技术信息

CAS号

59338-87-3

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H22ClN5O2

运输

蓝冰

分子量

351.83

别名

Alizapride (hydrochloride);Alizapride;59338-93-1;Limican;Plitican;Vergentan;Superan;Alizaprida;Litican;MS-5080;盐酸阿立必利

溶解度

DMSO	42.0 mg/mL (119.4 mM)
Water	69.0 mg/mL (196.1 mM)
Ethanol	Insoluble

动物实验配方

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