CAS No.: 897383-62-9
Allitinib Catalog No. CSN16578
Synonyms: AST-1306;ALS 1306;AST-6
AST-1306 is an irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Zhang H, Wang YJ, et la. AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Cancer Lett. 2014 Aug 1;350(1-2):61-8.
- [2] Xie H, Lin L, et al. AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. PLoS One. 2011;6(7):e21487.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 897383-62-9 | 储存条件 |
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| 分子式 | C24H18ClFN4O2 | 运输 | 蓝冰 | |
| 分子量 | 448.87 | 别名 | AST-1306;ALS 1306;AST-6 |
