|5-甲基-2-((4-甲基-1H-咪唑-5-基)甲基)-2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚-1-酮盐酸盐|CsnPharm

CAS No.: 122852-69-1

Alosetron HCl/盐酸阿洛司琼 Catalog No. CSN10255

Synonyms: GR 68755C;GR 68755 Hydrochloride;GR 68755X Hydrochloride

Alosetron HCl is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Alosetron HCl is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). It blocked the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons in vitro, with half-maximal inhibition at approximately 55 nmol/L. Alosetron attenuated the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs^[1]. The protective effects of alosetron on TNBS (trinitrobenzenesulfonic acid)-induced colitis can be mediated by 5-HT3R (Hydroxytryptamine 3 receptor) ^[2]. Stress-induced visceral hyperalgesia was abolished when alosetron was injected intrathecally in intact rats or subcutaneously (0.3 mg/kg) in capsaicin-pretreated animals^[3]. Alosetron (10-100 mg/kg) showed dose-dependent inhibition of CRF (corticotropin releasing factor)-induced defecation in rats^[4]. The 5-HT(3)-receptor antagonist alosetron (30 mg/kg) and the histamine H(1)-receptor antagonist pyrilamine (5 mg/kg) markedly attenuated the response to luminal antigen^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00067561	Irritable Colon ... more >> Irritable Bowel Syndrome (IBS) Collapse <<	Phase 3	Completed	-	-
NCT01257477	-	-	Completed	-	-
NCT00370032	Irritable Colon	Phase 4	Completed	-	United Kingdom ... more >> GSK Investigational Site London, United Kingdom, W1G 8HU Collapse <<

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0229 mL
- 15.1143 mL
- 30.2286 mL
- 5 mM
- 0.6046 mL
- 3.0229 mL
- 6.0457 mL
- 10 mM
- 0.3023 mL
- 1.5114 mL
- 3.0229 mL

技术信息

CAS号

122852-69-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H19ClN4O

运输

蓝冰

分子量

330.81

别名

GR 68755C;GR 68755 Hydrochloride;GR 68755X Hydrochloride;GR 68755 HCl;GR68755X;Alosetron (hydrochloride);Alosetron HCl;Alosetron hydrochloride;Lotronex;GR-68755

溶解度

DMSO	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Alosetron HCl/盐酸阿洛司琼 Catalog No. CSN10255

靶点选择性

请登录您的专属账户

确认信息