|(2S,3R,4S,5S,6R)-4,5-二羟基-6-(羟甲基)-2-(((3S,4R,4aS)-8-氧代-4-乙烯基-3,4,4a,5,6,8-六氢吡喃并[3,4-c]吡喃-3-基)氧基)四氢-2H-吡喃-3-基 3,3',5-三羟基-[1,1'-联苯]-2-羧酸酯|CsnPharm

CAS No.: 21018-84-8

Amarogentin/苦龙胆酯苷 Catalog No. CSN27358

Synonyms: AG;苦龙胆酯苷

Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Amarogentin, a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots, has been suggested to exhibit many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Mice were orally treated with 25, 50, and 100 mg/kg amarogentin and with colchicine as a positive control. Amarogentin delayed the formation of liver fibrosis; decreased alanine aminotransferase, aspartate aminotransferase, malondialdehyde and hydroxyproline levels; and increased albumin, cyclic guanosine monophosphate, glutathione peroxidase, and superoxide dismutase levels. Moreover, amarogentin exhibited downregulation of α-smooth muscle actin and transforming growth factor-β₁ levels in immunohistochemical and Western blot analyses^[4]. Amarogentin as an agonist for TAS2R1 and other TAS2Rs promotes keratinocyte differentiation. Amarogentin inhibited in LAD-2 cells substance P-induced production of newly synthesized TNF-α, but the degranulation and release of stored histamine were not affected^[5]. Amarogentin induced potent, dose-dependent as well as time-dependent cytotoxic effects on the growth of SNU-16 human gastric cancer cells. Amarogentin also inhibited the colony forming capability of these tumor cells and its treatment led to morphological alterations in these cells in which the cells became withered and rounded, detached from one another and adopted irregular shapes while floating freely in the culture medium. In comparison to untreated control cells, the amarogentin treated cells with 10, 50 and 75 μM exhibited 32.5, 45.2 and 57.1 % apoptotic cells, respectively. Amarogentin induced potent and dose-dependent G2/M cell cycle arrest in these cells and led to downregulation of m-TOR, p-PI3K, PI3K, p-Akt and Akt and upregulation of cyclin D1 and cyclin E protein expressions^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7049 mL
- 8.5246 mL
- 17.0491 mL
- 5 mM
- 0.3410 mL
- 1.7049 mL
- 3.4098 mL
- 10 mM
- 0.1705 mL
- 0.8525 mL
- 1.7049 mL

技术信息

CAS号

21018-84-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C29H30O13

运输

蓝冰

分子量

586.54

别名

AG;苦龙胆酯苷

溶解度

DMSO	98.0 mg/mL (167.1 mM)
Water	Insoluble
Ethanol	50.0 mg/mL (85.2 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Amarogentin/苦龙胆酯苷 Catalog No. CSN27358

靶点选择性

请登录您的专属账户

确认信息