|2-(2-氨基-3-苯甲酰苯基)乙酸钠水合物|CsnPharm

CAS No.: 61618-27-7

Amfenac Sodium Hydrate/氨芬酸钠水合物 Catalog No. CSN12868

Synonyms: Amfenac (sodium salt hydrate);Amfenac sodium H2O;氨芬酸钠水合物

Amfenac Sodium Monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 COX2

IC50:150nM COX1

IC50:250nM
描述Amfenac Sodium Monohydrate is a COX-2 (cyclooxygenase-2) inhibitor. Amfenac affected both COX-2 transfected and non-transfected uveal melanoma cells in terms of their proliferation rates as well as their suppressive effects on macrophage cytotoxic activity^[3]. Treatment of UM (uveal melanoma) cell lines with amfenac prior to radiation led to a marked reduction in proliferation rates. There appears to be a radioprotective effect of amfenac on human fibroblasts^[4]. 5×10-4 M Amfenac Sodium Hydrate inhibits the release of the enzyme 35.3 and 16.3% in the presence of 10-8, and 10-7 M FMLP, respectively. Addition of 10-4 M Amfenac Sodium Hydrate causes 28.3% inhibition of aggregation of polgmorphonuclear leukocgtes (PMNs) during incubation for 16 min with 10-8 M FMLP^[5]. Moreover, Amfenac treatment significantly inhibited VEGF-induced tube formation and proliferation by EC. Amfenac treatment significantly reduced retinal prostanoid production and NV (neovascularization) in OIR^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3868 mL
- 16.9339 mL
- 33.8678 mL
- 5 mM
- 0.6774 mL
- 3.3868 mL
- 6.7736 mL
- 10 mM
- 0.3387 mL
- 1.6934 mL
- 3.3868 mL

技术信息

CAS号

61618-27-7

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H14NNaO4

运输

蓝冰

分子量

295.27

别名

Amfenac (sodium salt hydrate);Amfenac sodium H2O;氨芬酸钠水合物

溶解度

DMSO	58.0 mg/mL (196.4 mM)
Ethanol	4.0 mg/mL (13.5 mM)

动物实验配方

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靶点	Description	IC50
COX2		IC50:150nM
COX1		IC50:250nM

Amfenac Sodium Hydrate/氨芬酸钠水合物 Catalog No. CSN12868

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