CAS No.: 1608125-21-8
AMG319 Catalog No. CSN15834
Synonyms: ACP-319
AMG-319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, > 47-fold selectivity over other PI3Ks.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT02540928 Human Papillomavirus (HPV) ... more >> Positive or Negative Head and Neck Squamous Cell Carcinoma (HNSCC) of the Hypopharynx, Oropharynx, Oral Cavity, Supraglottis or Larynx Collapse << Phase 2 Terminated(Safety Reasons) - United Kingdom ... more >> Aintree University Hospital - Clatterbridge Cancer Centre Liverpool, United Kingdom, CH63 4JY Churchill Hospital, Blenheim H&N Unit Oxford, United Kingdom, OX3 7LE Poole Hospital Poole, United Kingdom, BH15 2JB Queen Alexandra Hospital, Department of Oral and Maxillofacial Surgery Portsmouth, United Kingdom, PO6 3LY Southampton General Hospital Southampton, United Kingdom, SO16 6YD Collapse << NCT01300026 Cancer Chroni... more >>c Lymphocytic Leukemia Diffuse Large Cell Lymphoma Hematologic Malignancies Hematology Leukemia Low Grade Lymphoma Lymphoma Mantle Cell Lymphoma Non-Hodgkin's Lymphoma Oncology Oncology Patients T Cell Lymphoma Tumors Collapse << Phase 1 Completed - United States, New Jersey ... more >> Research Site Hackensack, New Jersey, United States, 07601 United States, North Carolina Research Site Durham, North Carolina, United States, 27710 United States, Utah Research Site Salt Lake City, Utah, United States, 84112 Collapse << - 参考文献
- [1] Niemann CU, Mora-Jensen HI, et al. Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model. Clin Cancer Res. 2017 Jun 23.
- [2] Cushing TD, Hao X, et al. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. J Med Chem. 2015 Jan 8;58(1):480-511.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1608125-21-8 | 储存条件 |
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| 分子式 | C21H16FN7 | 运输 | 蓝冰 | |
| 分子量 | 385.40 | 别名 | ACP-319 |
