|氨基胍盐酸盐|CsnPharm

CAS No.: 1937-19-5

Aminoguanidine HCl/氨基胍盐酸盐 Catalog No. CSN10284

Synonyms: Pimagedine hydrochloride;GER-11;Aminoguanidinium chloride

Aminoguanidine HCl is a selective and irreversible iNOS inhibitor.

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400-920-2911

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技术信息

生物活性

描述Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, reduces levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, is an investigational drug for the treatment of diabetic nephropathy. Combination of sub-threshold dose of meloxicam (1 mg/kg) with increasing doses of aminoguanidine hydrochloride (30, 100 and 300 mg/kg) resulted in synergistic anti-inflammatory effect. Combined therapy with sub-threshold dose of aminoguanidine hydrochloride (30 mg/kg) with increasing doses of meloxicam (1, 3, 10 and 30 mg/kg) also resulted in synergistic anti-inflammatory effect^[3]. Combination of a subthreshold dose of rofecoxib (1 mg/kg) with increasing doses of aminoguanidine hydrochloride (30, 100 and 300 mg/kg) resulted in potentiated antinociception. Combined therapy with a subthreshold dose of aminoguanidine hydrochloride (30 mg/kg) with increasing doses of rofecoxib (1, 3, 10 and 30 mg/kg) also resulted in significant antinociception. Thus, rofecoxib and aminoguanidine hydrochloride act synergistically in their antinociceptive action in mice^[4]. The fever index calculated for rats pretreated with v-LNIO or with aminoguanidine and injected with LPS (lipopolisaccharide) was reduced by 43% and 72%, respectively, compared to that calculated for water-pretreated and LPS-injected rats. Whereas vL-NIO (Vinyl-L-NIO (N(5) - (1-Imino-3-butenyl) - ornithine) partly attenuated both phases of febrile rise in T(b), administration of aminoguanidine into the brain completely prevented fever induced by LPS^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00563758	Constipation ... more >>Chronic Disease Collapse <<	Not Applicable	Terminated	-	China ... more >> Queen Mary Hospital Hong Kong, China Collapse <<
NCT00139568	Constipation	Phase 3	Completed	-	Switzerland ... more >> Novartis Basel, Switzerland, 4056 Collapse <<
NCT00149877	Chronic Constipation	Phase 4	Completed	-	Switzerland ... more >> Novartis Basel, Switzerland, 4056 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 9.0460 mL
- 45.2300 mL
- 90.4600 mL
- 5 mM
- 1.8092 mL
- 9.0460 mL
- 18.0920 mL
- 10 mM
- 0.9046 mL
- 4.5230 mL
- 9.0460 mL

技术信息

CAS号

1937-19-5

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

CH7ClN4

运输

蓝冰

分子量

110.55

别名

Pimagedine hydrochloride;GER-11;Aminoguanidinium chloride;Guanyl Hydrazine;Hydrazinecarboximidamide;Imino Semicarbazide;Monoaminoguanidine;Aminoguanidine (hydrochloride);MDL-201228;YM-585;GER11. aminoguanidine. Pimagedine hydrochloride;Guanylhydrazine hydrochloride;氨基胍盐酸盐

溶解度

DMSO	22.0 mg/mL (199.0 mM) warming
Ethanol	Insoluble

动物实验配方

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Aminoguanidine HCl/氨基胍盐酸盐 Catalog No. CSN10284

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