|4-((7-氯喹啉-4-基)氨基)-2-((二乙胺基)甲基)苯酚二水合物二盐酸盐|CsnPharm

CAS No.: 6398-98-7

Amodiaquine 2HCl Dihydrate/阿莫地喹二盐酸盐二水合物 Catalog No. CSN13910

Synonyms: Amodiaquin dihydrochloride dihydrate;Amodiaquin dihydrochloride;Amodiaquine hydrochloride dihydrate

Amodiaquine 2HCl is an inhibitor of histamine N-methyltransferase inhibitor with antimalarial and anti-inflammatory activities.

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技术信息

生物活性

描述Amodiaquin Dihydrochloride Dihydrate is a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor^[3]. Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β,interleukin-6,TNF-α and iNOS) in a dose-dependent manner. Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA)-induced cell death in primary dopamine cells as examined by the number of TH+ neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells^[4]. Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice^[5].The administration of amodiaquine (2 mg/kg, 5 mg/kg, s.c.) partially improved the survival rate of the C57BL/6 mice, Amodiaquine (2 mg/kg) decreased the LPS-induced increase in serum ALT levels at 6 h and AST levels at 6 h, whereas amodiaquine (5 mg/kg) decreased the LPS-induced increase in serum ALT levels at 3 h and 6 h and AST levels at 6 h. Amodiaquine dose-dependently lowered TNF-α levels in comparison to the saline treated mice, and abolished the increase in TNF-α mRNA in liver of P. acnes-primed and LPS-treated mice^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1514 mL
- 10.7570 mL
- 21.5140 mL
- 5 mM
- 0.4303 mL
- 2.1514 mL
- 4.3028 mL
- 10 mM
- 0.2151 mL
- 1.0757 mL
- 2.1514 mL

技术信息

CAS号

6398-98-7

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H28Cl3N3O3

运输

蓝冰

分子量

464.81

别名

Amodiaquin dihydrochloride dihydrate;Amodiaquin dihydrochloride;Amodiaquine hydrochloride dihydrate;Amodiaquine 2H2O HCl;阿莫地喹盐酸盐

溶解度

DMSO	92.0 mg/mL (197.9 mM)
Ethanol	Insoluble

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Amodiaquine 2HCl Dihydrate/阿莫地喹二盐酸盐 二水合物 Catalog No. CSN13910

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Amodiaquine 2HCl Dihydrate/阿莫地喹二盐酸盐二水合物 Catalog No. CSN13910