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CAS No.: 83-07-8

Ampyrone/4-氨基安替吡啉 Catalog No. CSN19498

Synonyms: 4-Aminoantipyrine;4-氨基安替比林

4-Aminoantipyrine is used as a reagent for glucose determination in the presence of peroxidase and phenol, it is a metabolite of aminopyrine with analgesic, anti-inflammatory and antipyretic properties.

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技术信息

生物活性

描述4-Aminoantipyrine (4-AA), a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). 4-AA did not cause genotoxic/mutagenic damage, splenic phagocytosis, or leukocyte alterations. However, when combined with the antineoplastic agents, 4-AA decreased their genotoxic, mutagenic, apoptotic, and phagocytic effects. 4-AA might interfere with DNA damage-mediated chemotherapy^[3]. 4-Aminoantipyrine was utilized as key intermediate for the synthesis of pyrazolone derivatives bearing biologically active moieties^[4]. Dp (Dipyrone) and AA (4-aminoantipyrine) increased gastric compliance and AA delayed GE, with the participation of the vagus nerve, through a pathway that does not involve a direct action of the drug on the central nervous system. AA and Dp administered iv significantly increased gastric retention (64.4 +/- 2.5 and 54.3 +/- 3.8%, respectively) compared to control (34 +/- 2.2%), a phenomenon observed only with Dp after icv administration^[5]. AAP can interact with CAT (antioxidant enzyme catalase) to form an AAP-CAT complex. Furthermore, the binding of AAP can inhibit CAT activity in erythrocytes. Exposure to AAP could induce changes in the enzyme CAT structure and function^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.9203 mL
- 24.6015 mL
- 49.2029 mL
- 5 mM
- 0.9841 mL
- 4.9203 mL
- 9.8406 mL
- 10 mM
- 0.4920 mL
- 2.4601 mL
- 4.9203 mL

技术信息

CAS号

83-07-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H13N3O

运输

蓝冰

分子量

203.24

别名

4-Aminoantipyrine;4-氨基安替比林

溶解度

DMSO	38.0 mg/mL (187.0 mM)
Water	38.0 mg/mL (187.0 mM)
Ethanol	40.0 mg/mL (196.8 mM)

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