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CAS No.: 486443-73-6

AN1 Catalog No. CSN25321

Synonyms: GKN-43736

LC3-mHTT-IN-1 is a mHTT-LC3 linker compound, which interacts with mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.

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生物活性

实验方案

技术信息

生物活性

描述Mutant huntingtin protein (mHTT) contains an expanded polyglutamine tract and causes Huntington's disease (HD). Microtubule-associated proteins 1A/1B light chain 3B (LC3) is a protein associated with autophagy substrate selection and autophagosome biogenesis. mHTT can be degraded by autophagy, during which protein substrates are incorporated into autophagosomes associated with LC3. LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mHTT and LC3, but not with wild-type HTT. LC3-mHTT-IN-AN1 at concentrations of 10 – 300nM reduced the level of mHTT in cultured HD mouse neurons in an allele-selective manner. LC3-mHTT-IN-AN1 also reduced the level of mutant but not wild-type ATXN3 in primary fibroblasts from patients with spinocerebellar ataxia type 3. Treatment with LC3-mHTT-IN-AN1 (2 μl at 25 μM per day) for 10 days led to a significant lowering of mHTT in the cortices of HD mice^[1].
参考文献

[1] Li Z, Wang C, Wang Z, Zhu C, Li J, Sha T, Ma L, Gao C, Yang Y, Sun Y, Wang J, Sun X, Lu C, Difiglia M, Mei Y, Ding C, Luo S, Dang Y, Ding Y, Fei Y, Lu B. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209. doi: 10.1038/s41586-019-1722-1

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4328 mL
- 12.1641 mL
- 24.3282 mL
- 5 mM
- 0.4866 mL
- 2.4328 mL
- 4.8656 mL
- 10 mM
- 0.2433 mL
- 1.2164 mL
- 2.4328 mL

技术信息

CAS号

486443-73-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H9Br2NO3

运输

蓝冰

分子量

411.04

别名

GKN-43736

溶解度

DMSO	120.0 mg/mL (291.9 mM) warming
Water	Insoluble

动物实验配方

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AN1 Catalog No. CSN25321

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