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CAS No.: 73218-79-8

Apraclonidine HCl Catalog No. CSN18702

Synonyms: ALO 2145;p-Aminoclonidine HCl;Apraclonidine (hydrochloride)

Apraclonidine HCl is a clonidine-derived selective agonist of alpha2-adrenergic receptor.

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技术信息

生物活性

描述Apraclonidine hydrochloride is a topical ophthalmic solution with selective alpha-2 and weak alpha-1 receptor agonist activity that has the ability to elevate the eye lid^[3]. Apraclonidine treatment resulted in significantly more patients achieving either an additional > or = 20% reduction in IOP(intraocular pressure) from baseline^[4]. Chronic administration of apraclonidine hydrochloride 0.5% produces no observable optic nerve vasomotor effects in the rabbit eye^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01058278	Glaucoma Infl... more >>ammatory Response Collapse <<	Not Applicable	Completed	-	Canada, Quebec ... more >> Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec Québec, Quebec, Canada, G1S 4L8 Collapse <<
NCT01956942	Open Angle Glaucoma	Phase 4	Completed	-	United States, District of Col... more >>umbia George Washington University Medical Faculty Associates Washington, District of Columbia, United States, 20037 Collapse <<
NCT01126203	Exfoliation Syndrome ... more >> Ocular Hypertension Collapse <<	Phase 3	Completed	-	Canada, Alberta ... more >> Rockyview General Hospital Eye Clinic Calgary, Alberta, Canada, T2V1P9 Canada, Ontario St. Joseph's Health Care London Eye Clinic London, Ontario, Canada, N6A 4V2 University of Ottawa Eye Institute Ottawa, Ontario, Canada, K1H 8L6 Dr. C Birt Toronto, Ontario, Canada, M4N 3M5 Canada, Quebec Montreal Glaucoma Institute Montreal, Quebec, Canada, H1V 1G5 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5515 mL
- 17.7576 mL
- 35.5152 mL
- 5 mM
- 0.7103 mL
- 3.5515 mL
- 7.1030 mL
- 10 mM
- 0.3552 mL
- 1.7758 mL
- 3.5515 mL

技术信息

CAS号

73218-79-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C9H11Cl3N4

运输

蓝冰

分子量

281.57

别名

ALO 2145;p-Aminoclonidine HCl;Apraclonidine (hydrochloride);AL0 2145;Iopidine HCl;Iopidine hydrochloride;Apraclonidine HCl;盐酸安普乐定

溶解度

DMSO	56.0 mg/mL (198.9 mM)
Water	18.0 mg/mL (63.9 mM)
Ethanol	4.0 mg/mL (14.2 mM)

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01058278	Glaucoma Infl... more >>ammatory Response Collapse <<	Not Applicable	Completed	-	Canada, Quebec ... more >> Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec Québec, Quebec, Canada, G1S 4L8 Collapse <<
NCT01956942	Open Angle Glaucoma	Phase 4	Completed	-	United States, District of Col... more >>umbia George Washington University Medical Faculty Associates Washington, District of Columbia, United States, 20037 Collapse <<
NCT01126203	Exfoliation Syndrome ... more >> Ocular Hypertension Collapse <<	Phase 3	Completed	-	Canada, Alberta ... more >> Rockyview General Hospital Eye Clinic Calgary, Alberta, Canada, T2V1P9 Canada, Ontario St. Joseph's Health Care London Eye Clinic London, Ontario, Canada, N6A 4V2 University of Ottawa Eye Institute Ottawa, Ontario, Canada, K1H 8L6 Dr. C Birt Toronto, Ontario, Canada, M4N 3M5 Canada, Quebec Montreal Glaucoma Institute Montreal, Quebec, Canada, H1V 1G5 Collapse <<
NCT00567411	Glaucoma Ocul... more >>ar Hypertension Collapse <<	Not Applicable	Unknown	June 2009	United States, District of Col... more >>umbia Walter Reed Army Medical Center Recruiting Washington, District of Columbia, United States, 20307 Contact: Vladimir S Yakopson, MD 202-782-6965 vladimir.yakopson@na.amedd.army.mil Sub-Investigator: William Wilson, MD Collapse <<
NCT01956942	Open Angle Glaucoma	Phase 4	Completed	-	United States, District of Col... more >>umbia George Washington University Medical Faculty Associates Washington, District of Columbia, United States, 20037 Collapse <<
NCT01126203	Exfoliation Syndrome ... more >> Ocular Hypertension Collapse <<	Phase 3	Completed	-	Canada, Alberta ... more >> Rockyview General Hospital Eye Clinic Calgary, Alberta, Canada, T2V1P9 Canada, Ontario St. Joseph's Health Care London Eye Clinic London, Ontario, Canada, N6A 4V2 University of Ottawa Eye Institute Ottawa, Ontario, Canada, K1H 8L6 Dr. C Birt Toronto, Ontario, Canada, M4N 3M5 Canada, Quebec Montreal Glaucoma Institute Montreal, Quebec, Canada, H1V 1G5 Collapse <<
NCT01058278	Glaucoma Infl... more >>ammatory Response Collapse <<	Not Applicable	Completed	-	Canada, Quebec ... more >> Centre universitaire d'ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec Québec, Quebec, Canada, G1S 4L8 Collapse <<
NCT00567411	Glaucoma Ocul... more >>ar Hypertension Collapse <<	Not Applicable	Unknown	June 2009	United States, District of Col... more >>umbia Walter Reed Army Medical Center Recruiting Washington, District of Columbia, United States, 20307 Contact: Vladimir S Yakopson, MD 202-782-6965 vladimir.yakopson@na.amedd.army.mil Sub-Investigator: William Wilson, MD Collapse <<

Apraclonidine HCl Catalog No. CSN18702

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