|(3R,4R)-4-(3,4-二甲氧基苄基)-3-(3-甲氧基-4-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)苄基)二氢呋喃-2(3H)-酮|CsnPharm

CAS No.: 20362-31-6

Arctiin/牛蒡子苷 Catalog No. CSN12574

Synonyms: Arctii;NSC 315527;Arctigenin-4-glucoside

Arctiin is a suppressor of cyclin D1 protein expression in multiple types of human tumor cells and also shows antiviral activity against influenza A.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Arctiin is a major lignan constituent of Arctium lappa and has anti-cancer properties. It could down-regulate cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer. The dephosphorylation of the tumor-suppressor retinoblastoma protein and growth inhibition induced by arctiin could be observed in human immortalized keratinocyte HaCaT cells^[7]. Combined treatment with arctiin potentiated the effect onf oseltamivir on reduction of the virus yields in both bronchoalveolar lavage fluids and lungs of mice infected with IFV (influenza A virus (A/NWS/33, H1N1))^[8]. Arctiin also works as an adiponectin receptor 1 agonist with IC50 value of 1.2μM^[9].

动物研究

剂量

Rat: 30 mg/kg - 120 mg/kg^[4] (p.o.) Guinea pig: 12.5 mg/kg - 50 mg/kg^[5]

给药途径

p.o.

动物药代数据

Animal	Rats^[6]
Dose	25 mg/kg
Administration	p.o.
T_1/2	15.9 ± 1.1 h
T_max	2.67 ± 1.15 h
CL	2.12 ± 0.13 l·kg/h
C_max	0.64 ± 0.23 mg/l
AUC_0→t	13.6 ± 5.7 mg·h/l

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8707 mL
- 9.3536 mL
- 18.7072 mL
- 5 mM
- 0.3741 mL
- 1.8707 mL
- 3.7414 mL
- 10 mM
- 0.1871 mL
- 0.9354 mL
- 1.8707 mL

技术信息

CAS号

20362-31-6

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H34O11

运输

蓝冰

分子量

534.55

别名

Arctii;NSC 315527;Arctigenin-4-glucoside;牛蒡子苷

溶解度

DMSO	98.0 mg/mL (183.3 mM)
Water	38.0 mg/mL (71.1 mM)
Ethanol	100.0 mg/mL (187.1 mM)

动物实验配方

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