CAS No.: 1056901-62-2
AT13148 Catalog No. CSN13758
AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01585701 Advanced Solid Tumours Phase 1 Completed - United Kingdom ... more >> Royal Marsden Hospital, Institute of Cancer Research Sutton, Surrey, United Kingdom, SM2 5PT Collapse << - 参考文献
- [1] Xi Y, Niu J, et al. AT13148, a first-in-class multi-AGC kinase inhibitor, potently inhibits gastric cancer cells both in vitro and in vivo. Biochem Biophys Res Commun. 2016 Sep 9;478(1):330-336.
- [2] Yap TA, Walton MI, et al. AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Clin Cancer Res. 2012 Jul 15;18(14):3912-23.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1056901-62-2 | 储存条件 |
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| 分子式 | C17H16ClN3O | 运输 | 蓝冰 | |
| 分子量 | 313.78 | 别名 |
