CAS No.: 1431697-85-6
AT7519 TFA Catalog No. CSN17844
Synonyms: AT7519M TFA;AT-7519 trifluoroacetate
AT 7519 trifluoroacetate is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM and less potent to CDK3 and little active to CDK7.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Santo L, Vallet S, et al.AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3beta activation and RNA polymerase II inhibition.Oncogene. 2010 Apr 22;29(16):2325-36. Epub 2010 Jan 25.
- [2] Squires MS, Feltell RE, et al. Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Mol Cancer Ther. 2009 Feb;8(2):324-32.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1431697-85-6 | 储存条件 |
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| 分子式 | C18H18Cl2F3N5O4 | 运输 | 蓝冰 | |
| 分子量 | 496.27 | 别名 | AT7519M TFA;AT-7519 trifluoroacetate |
