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CAS No.: 479413-70-2

AUDA Catalog No. CSN25287

AUDA is a potent soluble epoxide hydrolase (sEH) inhibitor with IC50s of 18 and 69 nM for the mouse and human sEH, respectively and with anti-inflammatory activity.

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技术信息

生物活性

描述The soluble epoxide hydrolase (sEH) is involved in the metabolism of arachidonic, linoleic, and other fatty acid epoxides, endogenous chemical mediators that play an important role in blood pressure regulation and inflammation. AUDA is a potent sEH inhibitor with IC₅₀s of 18±1 and 69±2 nM for the mouse and human sEH, respectively^[1]. AUDA (0.3 to 10 μg/mL) dose-dependently suppressed the proliferation of rat VSMCs (vascular smooth muscle cells) exposed to PDGF (platelet-derived growth factor) for 48 h. AUDA (1–30 μg/mL) dose-dependently inhibited the protein expression of Pin1 and increased HO-1 (heme oxygenase-1) protein levels in PDGF-treated VSMCs at a dose of 3 μg/mL, although potent induction was seen only at 30 μg/mL. PDGF increased COX-2 protein levels in rat VSMCs, and AUDA (1–30 μg/mL; 30 min) dose-dependently upregulated COX-2 expression^[2]. Furthermore, in the mouse model of Kawasaki disease (KD), AUDA reduced the protein expression of MMP-9, IL-1β and TNF-α, indicating that AUDA may alleviate inflammatory reactions in the coronary arteries of KD model mice^[3].
参考文献

[1] Morisseau C, Goodrow MH, Newman JW, Wheelock CE, Dowdy DL, Hammock BD. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochem Pharmacol. 2002;63(9):1599-1608
[2] Kim HS, Kim SK, Kang KW. Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells. Int J Mol Sci. 2017;18(12):2683
[3] Dai N, Zhao C, Kong Q, Li D, Cai Z, Wang M. Vascular repair and anti-inflammatory effects of soluble epoxide hydrolase inhibitor. Exp Ther Med. 2019;17(5):3580-3588

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5473 mL
- 12.7364 mL
- 25.4728 mL
- 5 mM
- 0.5095 mL
- 2.5473 mL
- 5.0946 mL
- 10 mM
- 0.2547 mL
- 1.2736 mL
- 2.5473 mL

技术信息

CAS号

479413-70-2

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H40N2O3

运输

蓝冰

分子量

392.58

别名

溶解度

DMSO	77.0 mg/mL (196.1 mM)
Water	Insoluble
Ethanol	6.0 mg/mL (15.3 mM)

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AUDA Catalog No. CSN25287

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