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CAS No.: 163768-50-1

Auristatin F/澳瑞他汀 F Catalog No. CSN17976

Synonyms: 澳瑞他汀 F

Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.

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技术信息

生物活性

描述Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02855359	Diffuse, Large B-Cell, Lymphom... more >>a Follicular Lymphoma, Grade 3b Transformed Lymphoma / DLBCL Collapse <<	Phase 2	Terminated(Sponsor decision ba... more >>sed on portfolio prioritization) Collapse <<	-	-
NCT02064387	Multiple Myeloma	Phase 1	Active, not recruiting	September 28, 2020	United States, Massachusetts ... more >> GSK Investigational Site Boston, Massachusetts, United States, 02215 United States, Michigan GSK Investigational Site Ann Arbor, Michigan, United States, 48109 United States, Missouri GSK Investigational Site Saint Louis, Missouri, United States, 63110 United States, New York GSK Investigational Site New York, New York, United States, 10065 United States, North Carolina GSK Investigational Site Chapel Hill, North Carolina, United States, 27599-7600 United States, Pennsylvania GSK Investigational Site Philadelphia, Pennsylvania, United States, 19104 United States, Texas GSK Investigational Site Dallas, Texas, United States, 75390-8565 United States, Washington GSK Investigational Site Seattle, Washington, United States, 98109 Canada, British Columbia GSK Investigational Site Vancouver, British Columbia, Canada, V5Z 1M9 Canada, Ontario GSK Investigational Site Toronto, Ontario, Canada, M5G 2M9 United Kingdom GSK Investigational Site London, United Kingdom, NW1 2BU GSK Investigational Site Manchester, United Kingdom, M20 4BX Collapse <<
NCT01508312	Hodgkin's Lymphoma	Phase 2	Active, not recruiting	September 2019	United States, New York ... more >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse <<

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参考文献

[1] Temming K, Meyer DL, et al. Improved efficacy of alphavbeta3-targeted albumin conjugates by conjugation of a novel auristatin derivative. Mol Pharm. 2007 Sep-Oct;4(5):686-94.
[2] Doronina SO, Mendelsohn BA, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3405 mL
- 6.7025 mL
- 13.4050 mL
- 5 mM
- 0.2681 mL
- 1.3405 mL
- 2.6810 mL
- 10 mM
- 0.1341 mL
- 0.6703 mL
- 1.3405 mL

技术信息

CAS号	163768-50-1	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C40H67N5O8	运输	蓝冰
分子量	745.99	别名	澳瑞他汀 F

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02855359	Diffuse, Large B-Cell, Lymphom... more >>a Follicular Lymphoma, Grade 3b Transformed Lymphoma / DLBCL Collapse <<	Phase 2	Terminated(Sponsor decision ba... more >>sed on portfolio prioritization) Collapse <<	-	-
NCT02064387	Multiple Myeloma	Phase 1	Active, not recruiting	September 28, 2020	United States, Massachusetts ... more >> GSK Investigational Site Boston, Massachusetts, United States, 02215 United States, Michigan GSK Investigational Site Ann Arbor, Michigan, United States, 48109 United States, Missouri GSK Investigational Site Saint Louis, Missouri, United States, 63110 United States, New York GSK Investigational Site New York, New York, United States, 10065 United States, North Carolina GSK Investigational Site Chapel Hill, North Carolina, United States, 27599-7600 United States, Pennsylvania GSK Investigational Site Philadelphia, Pennsylvania, United States, 19104 United States, Texas GSK Investigational Site Dallas, Texas, United States, 75390-8565 United States, Washington GSK Investigational Site Seattle, Washington, United States, 98109 Canada, British Columbia GSK Investigational Site Vancouver, British Columbia, Canada, V5Z 1M9 Canada, Ontario GSK Investigational Site Toronto, Ontario, Canada, M5G 2M9 United Kingdom GSK Investigational Site London, United Kingdom, NW1 2BU GSK Investigational Site Manchester, United Kingdom, M20 4BX Collapse <<
NCT01508312	Hodgkin's Lymphoma	Phase 2	Active, not recruiting	September 2019	United States, New York ... more >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse <<
NCT01672775	Carcinoma, Renal Cell ... more >> Renal Cell Carcinoma of Papillary Histology Renal Cell Carcinoma With Clear Cell Histology Renal Cell Carcinoma With Non-Clear Cell Histology Collapse <<	Phase 1	Completed	-	United States, Michigan ... more >> Site US00005 University of Michigan Medical Center Ann Arbor, Michigan, United States, 48109 Site US00003 Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, New York Site US00004 Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Site US00002 Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Washington Site US00001 Seattle Cancer Care Alliance Seattle, Washington, United States, 98109 Canada, Alberta Site CA00006 Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, British Columbia Site CA00008 British Columbia Cancer Agency Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Ontario Site CA00009 London Health Sciences Centre London, Ontario, Canada, N6A 4L6 Canada, Quebec Site CA00007 Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Collapse <<

Auristatin F/澳瑞他汀 F Catalog No. CSN17976

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