生物活性

• 描述Avatrombopag is an orally-active thrombopoietin (TPO) receptor agonist with EC50 of 3.3 nM.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01355289	Thrombocytopenia	Phase 2	Completed	-	United States, California ... more >> Health Care Consultants Los Angeles, California, United States United States, Virginia Metropolitan Research Fairfax, Virginia, United States, 22031 Collapse <<
  NCT01355289	-	-	Completed	-	-
  NCT00625443	Idiopathic Thrombocytopenic Pu... more >>rpura Collapse <<	Phase 2	Completed	-	United States, California ... more >> Pacific Cancer Medical Center, Inc Anaheim, California, United States, 92801 Comprehensive Blood and Cancer Center Bakersfield, California, United States, 93309 United States, Connecticut Davis, Posteraro and Wasser, MDs, LLP Manchester, Connecticut, United States, 06105 United States, Florida Florida Cancer Institute New Port Richey, Florida, United States, 34655 United States, Illinois John H. Stroger, Jr. Hospital of Cook County, Div. of Hematology and Oncology Chicago, Illinois, United States, 60612 United States, Indiana Cancer Care Center, Inc. New Albany, Indiana, United States, 47150 United States, Missouri Capitol Comprehensive Cancer Care Clinic Jefferson City, Missouri, United States, 65109 Kansas City Cancer Center, LLC Kansas City, Missouri, United States, 64131 United States, New York Mount Sinai Medical Center New York, New York, United States, 10029 New York Presbyterian Hospital, Weill Medical College of Cornell University New York, New York, United States, 10032 United States, North Carolina Emerywood Oncology and Hematology High Point, North Carolina, United States, 27262 United States, Ohio Mid Ohio Oncology/Hematology, Inc., dba The Mark H. Zangmeister Center Columbus, Ohio, United States, 43219 Collapse <<

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• 参考文献

• [1] Abe M, Suzuki K, et al. Pharmacological profile of AS1670542, a novel orally-active human thrombopoietin receptor agonist. Eur J Pharmacol. 2011 Jan 10;650(1):58-63.

  [2] Fukushima-Shintani M, Suzuki K, et al. AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur J Haematol. 2009 Apr;82(4):247-54.