|(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(二甲基氨基)-3-羟基-3-羟基-6-甲基四氢-2H-吡喃-2-基)氧基)-2-乙基-3,4,10-三羟基-13-(((2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢-2H-吡喃-2-基)氧基]-3,5,8,10,12,14-六甲基-14-甲基-1-氧杂-6-氮杂环十五烷-15-酮|CsnPharm

CAS No.: 76801-85-9

Azathramycin/去甲基阿奇霉素 Catalog No. CSN10188

Synonyms: Azaerythromycin A;Desmethyl Azithromycin;9-Deoxo-9a-Aza-9a-homoerythromycin A

Azathramycin is an antibiotic used for the treatment of a number of bacterial infections with elimination half-life‎ of ‎11–14 h.

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描述Azithromycin is an azalide, a subclass of macrolide antibiotics. It prevents bacteria from growing by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome and thus inhibits translation of mRNA. Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear infections, strep throat, pneumonia, typhoid, bronchitis, and sinusitis. In recent years, it has been used primarily to prevent bacterial infections in infants and those with weaker immune systems^[3]. Azithromycin significantly reduced the risk of bronchopulmonary dysplasia (BPD) in extremely premature neonates^[4]. Azithromycin did not reduce the rate of severe exacerbations and LRTI (lower respiratory tract infections) in patients with severe asthma^[5]. Azithromycin treatment induced a perturbation in the gut microbiota 14 days after randomization but did not have long-lasting effects on the gut microbiota composition^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.3606 mL
- 6.8031 mL
- 13.6062 mL
- 5 mM
- 0.2721 mL
- 1.3606 mL
- 2.7212 mL
- 10 mM
- 0.1361 mL
- 0.6803 mL
- 1.3606 mL

技术信息

CAS号

76801-85-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C37H70N2O12

运输

蓝冰

分子量

734.96

别名

Azaerythromycin A;Desmethyl Azithromycin;9-Deoxo-9a-Aza-9a-homoerythromycin A;去甲基阿奇霉素;阿扎霉素

溶解度

DMSO	140.0 mg/mL (190.5 mM)
Water	insoluble

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