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CAS No.: 1092453-15-0
Synonyms: AZD-8529
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00921804 | Schizophrenia | Phase 2 | Completed | - | United States, California ... more >> Research Site Garden Grove, California, United States Research Site Glendale, California, United States United States, Maryland Research Site Rockville, Maryland, United States Collapse << |
NCT00985933 | Healthy Memor... more >>y Impairment Collapse << | Early Phase 1 | Completed | - | United States, Connecticut ... more >> Research Site New Haven, Connecticut, United States Collapse << |
NCT00886756 | Healthy | Phase 1 | Completed | - | United Kingdom ... more >> Research Site London, United Kingdom Collapse << |
实验方案
技术信息
CAS号 | 1092453-15-0 | 储存条件 |
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分子式 | C24H24F3N5O3 | 运输 | 蓝冰 | |
分子量 | 487.47 | 别名 | AZD-8529 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT00921804 | Schizophrenia | Phase 2 | Completed | - | United States, California ... more >> Research Site Garden Grove, California, United States Research Site Glendale, California, United States United States, Maryland Research Site Rockville, Maryland, United States Collapse << |
NCT00985933 | Healthy Memor... more >>y Impairment Collapse << | Early Phase 1 | Completed | - | United States, Connecticut ... more >> Research Site New Haven, Connecticut, United States Collapse << |
NCT00886756 | Healthy | Phase 1 | Completed | - | United Kingdom ... more >> Research Site London, United Kingdom Collapse << |
NCT00755378 | Healthy Volunteer | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Research Site Philadelphia, Pennsylvania, United States Collapse << |
NCT00986531 | Schizophrenia | Phase 1 | Completed | - | United States, Pennsylvania ... more >> Research Site Philadelphia, Pennsylvania, United States Collapse << |
NCT02401022 | Tobacco Use Disorder | Phase 2 | Completed | - | United States, California ... more >> Pharmacology Research Institute Encino, California, United States, 91316 Pacific Treatment and Research Center La Jolla, California, United States, 92037 Pharmacology Research Institute Los Alamitos, California, United States, 90720 Pharmacology Research Institute Newport Beach, California, United States, 92660 United States, Maryland University of Maryland - College Park College Park, Maryland, United States, 20742 United States, New York Columbia University Medical Center New York, New York, United States, 10019 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45229 United States, Pennsylvania Centers for the Studies of Addiction Philadelphia, Pennsylvania, United States, 19104 United States, Virginia Virginia Commonwelath University Richmond, Virginia, United States, 23219 Collapse << |
NCT02401022 | - | - | Completed | - | - |
NCT00765492 | Healthy Volunteer | Phase 1 | Completed | - | - |
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