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CAS No.: 1448671-31-5
Synonyms: AZD3965
AZD3965 is a potent, selective and orally available monocarboxylate transporter 1 (MCT1) inhibitor with a binding affinity of 1.6 nM.
生物活性
靶点 | MCT1 Ki:1.6nM |
动物研究 | |
剂量 | Mice[2] (p.o.): 100 mg/kg |
给药途径 | p.o. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01791595 | Adult Solid Tumor ... more >> Diffuse Large B Cell Lymphoma Burkitt Lymphoma Collapse << | Phase 1 | Recruiting | - | United Kingdom ... more >> Royal Marsden Hospital Active, not recruiting Sutton, London, United Kingdom, SM2 5PT The Beatson West of Scotland, Glasgow Recruiting Glasgow, United Kingdom Principal Investigator: Pam McKay, Dr Leicester Royal Infirmary Recruiting Leicester, United Kingdom Principal Investigator: Martin Dyer, Prof. The Christie Recruiting Manchester, United Kingdom Principal Investigator: Kim Linton, Dr Freeman Hospital Active, not recruiting Newcastle upon Tyne, United Kingdom, NE7 7DN Derriford Hospital Recruiting Plymouth, United Kingdom Principal Investigator: Simon Rule, Prof. Collapse << |
实验方案
技术信息
CAS号 | 1448671-31-5 | 储存条件 |
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分子式 | C21H24F3N5O5S | 运输 | 蓝冰 | |||||||||||||
分子量 | 515.51 | 别名 | AZD3965 | |||||||||||||
溶解度 |
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动物实验配方 |
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT01791595 | Adult Solid Tumor ... more >> Diffuse Large B Cell Lymphoma Burkitt Lymphoma Collapse << | Phase 1 | Recruiting | - | United Kingdom ... more >> Royal Marsden Hospital Active, not recruiting Sutton, London, United Kingdom, SM2 5PT The Beatson West of Scotland, Glasgow Recruiting Glasgow, United Kingdom Principal Investigator: Pam McKay, Dr Leicester Royal Infirmary Recruiting Leicester, United Kingdom Principal Investigator: Martin Dyer, Prof. The Christie Recruiting Manchester, United Kingdom Principal Investigator: Kim Linton, Dr Freeman Hospital Active, not recruiting Newcastle upon Tyne, United Kingdom, NE7 7DN Derriford Hospital Recruiting Plymouth, United Kingdom Principal Investigator: Simon Rule, Prof. Collapse << |
靶点 | Description | IC50 |
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MCT1 | Ki:1.6nM |
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