CAS No.: 1869912-40-2
AZD5153 6-Hydroxy-2-naphthoic acid/AZD-5153 6-羟基-2-萘甲酸 Catalog No. CSN20607
Synonyms: AZD-5153 HNT salt;AZD-5153;AZD-5153 6-hydroxy-2-naphthoate. AZD-5153 HNT salt
AZD5153 is an inhibitor of BET/BRD4 bromodomain, the IC50 for BRD4 is 1.7 nM.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 Bromodomain 4
IC50:1.7nM- 描述
- 参考文献
- [1] Rhyasen GW, Hattersley MM, et al. AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies. Mol Cancer Ther. 2016 Nov;15(11):2563-2574.
- [2] Bradbury RH, Callis R, et al. Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4] triazolo[4,3-b] pyridazin-6-yl)-4-piperidyl] phenoxy] ethyl] -1,3-dimethyl-piperazin-2-one (AZD5153). J Med Chem. 2016 Sep 8;59(17):7801-17.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1869912-40-2 | 储存条件 |
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| 分子式 | C36H41N7O6 | 运输 | 蓝冰 | |||||||
| 分子量 | 667.75 | 别名 | AZD-5153 HNT salt;AZD-5153;AZD-5153 6-hydroxy-2-naphthoate. AZD-5153 HNT salt | |||||||
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动物实验配方 |
