CAS No.: 149908-53-2
Azimilide Catalog No. CSN10370
Synonyms: NE-10064
Azimilide is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.
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靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00035490 Arrhythmia Phase 3 Completed - - NCT00035451 Atrial Fibrillation Phase 3 Completed - - NCT01097330 Defibrillators, Implantable ... more >> Tachycardia, Ventricular Collapse << Phase 3 Terminated(Anticipated non-fea... more >>sibility of recruitment objectives) Collapse << December 2014 United States, Illinois ... more >> Northwestern University Chicago, Illinois, United States, 60611 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Texas Texas Cardiac Arrhythmia Research Foundation Austin, Texas, United States, 78705 United States, Virginia University of Virginia Health System Charlottesville, Virginia, United States, 22908 Canada, Ontario Hamilton Health Sciences Hamilton, Ontario, Canada, L8L 2X2 Southlake Regional Health Centre Newmarket, Ontario, Canada, L3Y 2P9 University of Ottawa Heart Institute Ottawa, Ontario, Canada, K1Y 4W7 Canada, Quebec McGill University Health Center Montreal, Quebec, Canada, H3G 1A4 Canada Institut Universitaire de Cardiologie et Pneumologie de Québec Quebec, Canada, G1V 4G5 China Beijng Fuwai Heart Hospital Beijing, China, 100037 Collapse << - 更多
- 参考文献
- [1] Busch AE, Eigenberger B, et al. Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action. Br J Pharmacol. 1998 Jan;123(1):23-30.
- [2] Yao JA, Tseng GN. Azimilide (NE-10064) can prolong or shorten the action potential duration in canine ventricular myocytes: dependence on blockade of K, Ca, and Na channels. J Cardiovasc Electrophysiol. 1997 Feb;8(2):184-98.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 149908-53-2 | 储存条件 |
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| 分子式 | C23H28ClN5O3 | 运输 | 蓝冰 | |
| 分子量 | 457.95 | 别名 | NE-10064 |
