|(3S,5S,8R,9S,10S,13R,14S,17R)-10,13-二甲基-17-((R)-6-甲基庚-2-基)十六氢-1H-环戊烷并[a]菲-3-醇|CsnPharm

CAS No.: 80-97-7

β-Cholestanol/二氢胆固醇 Catalog No. CSN21608

Synonyms: Dihydrocholesterol;5α-Cholestanol;NSC 18188

Dihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs and other biological matter, it could reduce plasma cholesterol by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Dihydrocholesterol, also known as cholestanol or zymostanol, belongs to the class of organic compounds known as cholesterols and derivatives. Rabbits fed a diet containing 0.75% dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder^[1]. Whereas dihydrocholesterol exhibits a condensing power that is equivalent to that of cholesterol, the action of coprostanol is significantly weaker^[2]. Proliferation of the epithelial cells of the gall bladder during the initial stages of experimental cholelithiasis has been studied by autoradiography. Rabbits taking a diet with 1% dihydrocholesterol added showed a rise in labelling index from 1.5%-19% by three days^[3]. The auxotroph grows normally on desmosterol and trans-22-dehydrocholesterol and at reduced rates on dihydrocholesterol, campesterol, and 22,23-dihydrobrassicasterol. In cells grown with dihydrocholesterol, a marked increase in desaturation and elongation of fatty acids is noted^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01131832	Hyperlipidemia	Phase 4	Completed	-	United States, Maryland ... more >> USDA-ARS, Beltsville Human Nutrition Research Center Beltsville, Maryland, United States, 20705 Canada, Manitoba Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba Winnipeg, Manitoba, Canada, R3T 6C5 Collapse <<
NCT00867165	Primary Hypercholesterolemia	Phase 3	Completed	-	-
NCT01902394	Digestive Health and Immune Fu... more >>nction Collapse <<	Not Applicable	Completed	-	United States, Massachusetts ... more >> HNCRA at Tufts University Boston, Massachusetts, United States, 02111 Collapse <<

更多
参考文献

[1] Lee SP, Scott AJ. Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury. Br J Exp Pathol. 1979 Jun;60(3):231-8
[2] Daly TA, Wang M, Regen SL. The origin of cholesterol's condensing effect. Langmuir. 2011 Mar 15;27(6):2159-61
[3] Scott AJ. Epithelial cell proliferation in diverse models of experimental cholelithiasis. Gut. 1978 Jun;19(6):558-62
[4] Rujanavech C, Silbert DF. LM cell growth and membrane lipid adaptation to sterol structure. J Biol Chem. 1986 Jun 5;261(16):7196-203

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5729 mL
- 12.8644 mL
- 25.7288 mL
- 5 mM
- 0.5146 mL
- 2.5729 mL
- 5.1458 mL
- 10 mM
- 0.2573 mL
- 1.2864 mL
- 2.5729 mL

技术信息

CAS号

80-97-7

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H48O

运输

蓝冰

分子量

388.67

别名

Dihydrocholesterol;5α-Cholestanol;NSC 18188;Beta-Cholestanol;Zymostanol;5alpha-Cholestanol;Cholestanol;β-Cholestanol;(+)-Dihydrocholesterol;二氢胆固醇

溶解度

DMSO	insoluble
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01131832	Hyperlipidemia	Phase 4	Completed	-	United States, Maryland ... more >> USDA-ARS, Beltsville Human Nutrition Research Center Beltsville, Maryland, United States, 20705 Canada, Manitoba Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba Winnipeg, Manitoba, Canada, R3T 6C5 Collapse <<
NCT00867165	Primary Hypercholesterolemia	Phase 3	Completed	-	-
NCT01902394	Digestive Health and Immune Fu... more >>nction Collapse <<	Not Applicable	Completed	-	United States, Massachusetts ... more >> HNCRA at Tufts University Boston, Massachusetts, United States, 02111 Collapse <<
NCT01995149	Familial Hypercholesterolemias... more >> Weight Loss Familial Combined Hypercholesterolemia Obesity Collapse <<	Not Applicable	Completed	-	-
NCT00074464	-	-	Completed	-	-
NCT01205308	Type 1 Diabetes	Not Applicable	Completed	-	Finland ... more >> University of Eastern Finland Kuopio, Finland, FIN-70211 Collapse <<
NCT00018694	Cerebrotendinous Xanthomatosis	Not Applicable	Withdrawn	-	United States, New Jersey ... more >> VA New Jersey Health Care System, East Orange East Orange, New Jersey, United States, 07018 Collapse <<
NCT00867165	-	-	Completed	-	-
NCT03584893	-	-	Recruiting	June 1, 2019	Turkey ... more >> Çukurova University Medical Faculty Department of Ophtalmology Not yet recruiting Adana, Turkey Ankara University Medical Faculty Department of Ophtalmology Recruiting Ankara, Turkey Hacettepe University Medical Faculty Department of Ophtalmology Recruiting Ankara, Turkey SBU Gülhane Training and Research Hospital Not yet recruiting Ankara, Turkey Ulucanlar Göz Training Hospital Not yet recruiting Ankara, Turkey Akdeniz University Medical Faculty Department of Ophtalmology Recruiting Antalya, Turkey Uludağ University Medical Faculty Department of Ophtalmology Recruiting Bursa, Turkey Osmangazi University Medical Faculty Department of Ophtalmology Recruiting Eskişehir, Turkey Gaziantep University Şahinbey Training and Research Hospital Recruiting Gaziantep, Turkey Istanbul University Istanbul Medical Faculty Department of Ophtalmology Recruiting Istanbul, Turkey Marmara University Medical Faculty Department of Ophtalmology Not yet recruiting Istanbul, Turkey Prof.Dr.N.Reşat Belger Beyoğlu Göz Training and Research Hospital Not yet recruiting Istanbul, Turkey Dokuz Eylül University Medical Faculty Department of Ophtalmology Recruiting İzmir, Turkey Ege University Medical Faculty Department of Ophtalmology Recruiting İzmir, Turkey Kayseri Training and Research Hospital Not yet recruiting Kayseri, Turkey Mersin University Medical Faculty Department of Ophtalmology Recruiting Mersin, Turkey Collapse <<
NCT00004346	Cerebrotendinous Xanthomatosis	Phase 2	Unknown	-	United States, Oregon ... more >> Oregon Health and Science University Recruiting Portland, Oregon, United States, 97239-3098 Contact: Sonja Connor 503-494-7775 connors@ohsu.edu Collapse <<

β-Cholestanol/二氢胆固醇 Catalog No. CSN21608

靶点选择性

请登录您的专属账户

确认信息