|2,6-二甲基-5-硝基-4-(2-(三氟甲基)苯基)-1,4-二氢吡啶-3-羧酸甲酯|CsnPharm

CAS No.: 71145-03-4

Bay K 8644 Catalog No. CSN19219

Synonyms: (±)-Bay K 8644;(±)-Bay K 864;SQ 28,873

Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The intracellular Ca²⁺ channel participates in a variety of signaling pathways, such as neurotransmitter release, hormonal activation, and T cell activation. Bay K 8644 is a dihydropyridine that acts as an L-type Ca²⁺ channel agonist.^[3] Bay K 8644 at a concentration of 10⁻⁶M increased L-type calcium current density by 127±4% and 103±5% in 2-day-old and 7-day-old newborn rat cardiomyocytes, respectively.^[4] A one-time dose of Bay K 8644 at 10μg/kg significantly elevated the mean arterial pressure in endotoxin-treated hypotensive rats, but had minimal effects on normal rats. It also led to a dose-dependent decrease in the heart rate of 37% in endotoxin-treated rats and 39% in control rats.^[5]
作用机制Bay K 8644 is a specific L-type Ca²⁺ channel agonist that enhances Ca²⁺ influx by increasing the open probability of sarcolemmal Ca Ca²⁺ channels.^[3]
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8067 mL
- 14.0333 mL
- 28.0665 mL
- 5 mM
- 0.5613 mL
- 2.8067 mL
- 5.6133 mL
- 10 mM
- 0.2807 mL
- 1.4033 mL
- 2.8067 mL

技术信息

CAS号

71145-03-4

储存条件

粉末: Keep in dark place,Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H15F3N2O4

运输

蓝冰

分子量

356.30

别名

(±)-Bay K 8644;(±)-Bay K 864;SQ 28,873;BAYK-8644

溶解度

DMSO	270.0 mg/mL (757.8 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	5.4 mg/mL	clear
PO	0.5% CMC-Na	50 mg/mL	suspension

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Bay K 8644 Catalog No. CSN19219

靶点选择性

请登录您的专属账户

确认信息