CAS No.: 222638-67-7
BEC HCl Catalog No. CSN18781
Synonyms: BEC (hydrochloride);Loride
BEC HCl is a competitive arginase inhibitor with Ki of 0.31 μM and 0.4-0.6 μM for Arginase II and rat Arginase I respectively.
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- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03389022 Pain, Postoperative ... more >> Bariatric Surgery Candidate Collapse << Phase 4 Completed - - - 参考文献
- [1] Steppan J, Ryoo S, et al. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64.
- [2] Colleluori DM, Ash DE. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62.
- [3] Colleluori DM, Ash DE. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62
- [4] Ckless K, Lampert A, Reiss J, Kasahara D, Poynter ME, Irvin CG, Lundblad LK, Norton R, van der Vliet A, Janssen-Heininger YM. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol. 2008 Sep 15;181(6):4255-64
- [5] Lee SH, Ahn KM, Lee SY, Kim SS, Park HW. Blood Eosinophil Count as a Predictor of Lung Function Decline in Healthy Individuals. J Allergy Clin Immunol Pract. 2021 Jan;9(1):394-399.e1
实验方案
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技术信息
| CAS号 | 222638-67-7 | 储存条件 |
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| 分子式 | C5H13BClNO4S | 运输 | 蓝冰 | |||||
| 分子量 | 229.49 | 别名 | BEC (hydrochloride);Loride | |||||
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动物实验配方 |
