|(2R,3S,4R,5R,6R)-5-氨基-2-(氨基甲基)-6-(((1R,2S,3S,4R,6S)-4,6-二氨基-3-(((2S ,3R,4S,5S,6R)-4-氨基-3,5-二羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)-2-羟基环己基)氧基)四氢-2H-吡喃- 3,4-二醇|CsnPharm

CAS No.: 4696-76-8

Bekanamycin/卡那霉素 Catalog No. CSN11246

Synonyms: Kanamycin B;Kanendomycin;Nebramycin V

Bekanamycin is an aminoglycoside antibiotic acting through irreversibly binding to the bacterial 30S ribosomal subunit, leading to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis.

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技术信息

生物活性

描述Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain^[2]. Bekanamycin in a concentration-dependent fashion reduced reversibly the quantal content of the end-plate potentials while it had no observable effect on the configuration of the extracellularly recorded presynaptic action potential. Bekanamycin also reduced in a dose-dependent manner the acceleration of miniature end-plate potentials induced by increasing the extracellular K+ concentration while it had no effect on spontaneous miniature end-plate potential frequency in resting junctions. Besides its inhibitory pre-junctional effects bekanamycin in concentrations higher than 40 mM decreased dose-dependently the amplitude of miniature end-plate potentials^[3]. Each one of kanamycin (KM), bekanamycin (AKM) and ribostamycin (RSM) in concentrations of 1 x 10(-5) g/ml-1 x 10(-3) g/ml produced a concentration-dependent decreasing effect in the magnitude of the electrical stimulation-induced contractile response of the ureteral segment^[4].
参考文献

[1] Morales MA, Castrillon JL, et al. Effects of bekanamycin and dibekacin on the electrical activity of cardiac pacemaker cells. Arch Med Res. 1993 Winter;24(4):339-45.
[2] Gao W, Wu Z, Sun J, Ni X, Xia H. Modulation of kanamycin B and kanamycin A biosynthesis in Streptomyces kanamyceticus via metabolic engineering. PLoS One. 2017;12(7):e0181971. Published 2017 Jul 28
[3] Uchiyama T, Molgo J, Lemeignan M. Presynaptic effects of bekanamycin at the frog neuromuscular junction. Reversibility by calcium and aminopyridines. Eur J Pharmacol. 1981;72(4):271‐280
[4] Yoshida M, Koeda T. Effect of aminoglycoside antibiotics on the electrical stimulation-induced contractile response of the guinea-pig ureter. Nihon Heikatsukin Gakkai Zasshi. 1989;25(3):75‐87

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0682 mL
- 10.3410 mL
- 20.6819 mL
- 5 mM
- 0.4136 mL
- 2.0682 mL
- 4.1364 mL
- 10 mM
- 0.2068 mL
- 1.0341 mL
- 2.0682 mL

技术信息

CAS号

4696-76-8

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H37N5O10

运输

蓝冰

分子量

483.51

别名

Kanamycin B;Kanendomycin;Nebramycin V;NK-1006;卡那霉素;贝卡那霉素

溶解度

DMSO	insoluble
Water	205.0 mg/mL (424.0 mM)

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Bekanamycin/卡那霉素 Catalog No. CSN11246

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