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CAS No.: 5003-48-5

BENORILATE/贝诺酯 Catalog No. CSN10398

Synonyms: Salipran;Win-11450;Benoryilate

Benorylate HCl is an ester-linked codrug of aspirin with paracetamol, used as an anti-inflammatory and antipyretic medication.

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生物活性

描述Benorylate (4-acetamidophenyl 2-acetoxybenzoate) is a new esterified aspirin preparation whose antirheumatic properties are reported to be as good as those of aspirin^[3]. Benorylate (Salipran) causes a large decrease in the liver's conversion rate of lactate into glucose, an important component of glucose homeostasis. Benorylate (Salipran) also impairs the urea synthesis rate from ammonia, another important function of the liver^[4]. Benorylate is probably absorbed as the intact molecule which accounts for its good gastric tolerance. After absorption, benorylate is hydrolysed into its components, salicylate and paracetamol, which then follows the usual routes of metabolism^[5]. Benorylate 4 g twice daily was shown to be an effective analgesic and anti-inflammatory drug, its effects being indistinguishable from those of aspirin 1.2 g four times daily. The overall incidence of side effects was less with benorylate, though this difference was not significant at the 5% level^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1918 mL
- 15.9589 mL
- 31.9178 mL
- 5 mM
- 0.6384 mL
- 3.1918 mL
- 6.3836 mL
- 10 mM
- 0.3192 mL
- 1.5959 mL
- 3.1918 mL

技术信息

CAS号

5003-48-5

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H15NO5

运输

蓝冰

分子量

313.30

别名

Salipran;Win-11450;Benoryilate;TO-125;Fenasparate;贝诺酯

溶解度

DMSO	62.0 mg/mL (197.9 mM)

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