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CAS No.: 3818-50-6

Bephenium (hydroxynaphthoate)/羟萘酸苄酚宁 Catalog No. CSN10414

Synonyms: Alcopar;Bephenium hydroxynaphthoate;Naphthammon

Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis and is a B-type AChR activator.

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生物活性

描述Bephenium hydroxynaphthoate is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis; B-type AChR activator^[3]. A number of anthelmintic compounds like levamisole and pyrantel target the AChRs of nematodes producing spastic paralysis of the worms. The muscle AChRs of nematode parasites fall into three pharmacological classes that are preferentially activated by the cholinergic agonists levamisole (L-type), nicotine (N-type) and bephenium (B-type), respectively. Bephenium selectively activates the Hco-L-AChR1 subtype made of Hco-UNC-29.1, Hco-UNC-38, Hco-UNC-63, Hco-ACR-8 subunits that is more sensitive to levamisole than acetylcholine. Removing the Hco-ACR-8 subunit produced the Hco-L-AChR2 subtype that is more sensitive to pyrantel than acetylcholine and partially activated by levamisole, but which was bephenium-insensitive indicating that the bephenium-binding site involves Hco-ACR-8^[4]. On the other hand, bephenium was more potent against larvae of isolate PR (high-level resistance) than larvae of isolate NT (twofold) (low-level resistance) and nicotine had the same potency against larvae of both isolates^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2546 mL
- 11.2731 mL
- 22.5462 mL
- 5 mM
- 0.4509 mL
- 2.2546 mL
- 4.5092 mL
- 10 mM
- 0.2255 mL
- 1.1273 mL
- 2.2546 mL

技术信息

CAS号	3818-50-6	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C28H29NO4	运输	蓝冰
分子量	443.53	别名	Alcopar;Bephenium hydroxynaphthoate;Naphthammon;Naphthammonum;Nemex;羟萘酸苄酚宁

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