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CAS No.: 486-60-2

Bergaptol/香柑醇 Catalog No. CSN10419

Synonyms: 5-Hydroxypsoralen;4-Hydroxybergapten;Psoralin

Bergaptol is a hydroxylated psoralen isolated and purified from the root of Notopterygium incisum that acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 μM.

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技术信息

生物活性

描述Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM^[3]. Bergaptol specifically inhibited VBL (vinblastine) efflux^[4]. BER (Bergaptol) treatment significantly inhibited LPS-induced production of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and gene expression of inducible nitric oxide synthase (iNOS), IL-6, TNF-α, interleukin-1 beta (IL-1β) and cyclooxygenase-2 (COX-2). BER also potently blocked LPS-induced mitogen-activated protein kinase (MAPK) phosphorylation and nuclear factor-kappa B (NF-κB) activation, as evidenced by the inhibitory effects on c-Jun N-terminal kinase (JNK), P38, P65, IκBα and IκKα/β phosphorylation, and NF-κB nuclear translocation. Furthermore, BER treatment markedly mitigated ox-LDL-induced foam cell formation by inhibiting scavenger receptor class A type I (SRA1) and cluster of differentiation 36 (CD36)-dependent cholesterol uptake^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.9465 mL
- 24.7325 mL
- 49.4651 mL
- 5 mM
- 0.9893 mL
- 4.9465 mL
- 9.8930 mL
- 10 mM
- 0.4947 mL
- 2.4733 mL
- 4.9465 mL

技术信息

CAS号

486-60-2

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C11H6O4

运输

蓝冰

分子量

202.16

别名

5-Hydroxypsoralen;4-Hydroxybergapten;Psoralin

溶解度

DMSO	40.0 mg/mL (197.9 mM)

动物实验配方

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