|1-([1,1'-联苯基]-4-基(苯基)甲基)-1H-咪唑|CsnPharm

CAS No.: 60628-96-8

Bifonazole/联苯苄唑 Catalog No. CSN16770

Synonyms: Bay H-4502;Trifonazole;Mycospor

Bifonazole is a substituted imidazole antifungal agent, working by inhibiting the production of ergosterol, which is an essential component of fungal cell membranes.

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技术信息

生物活性

描述Bifonazole, a new broad-spectrum antimycotic, interferes with sterol biosynthesis. In contrast to clotrimazole, bifonazole possesses a sequential mode of action, namely inhibition of cytochrome P450-dependent C14-demethylation of sterols and direct inhibition of HMG-CoA-reductase^[3]. Bifonazole and clotrimazole are potent inhibitors of ergosterol synthesis in yeasts and dermatophytes. Inhibition of demethylation of 4,4',14-trimethylsterols is accepted as primary mode of action responsible for their fungistatic efficacy^[4]. Moreover, in PC3 human prostate cancer cells, bifonazole induced [Ca(2+)]i rises by inducing phospholipase C- and protein kinase C-dependent Ca(2+) release from the endoplasmic reticulum and Ca(2+) influx via non-store-operated pathways. Bifonazole (30-100 µM) induced apoptosis concentration-dependently^[5]. In the histamine wheal test and after UV radiation, Bifonazole showed antiphlogistic effects that were comparable to those of hydrocortisone^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01013909	Tinea Pedis	Phase 2	Completed	-	Germany ... more >> Berlin, Germany, 10437 Berlin, Germany, 13055 Berlin, Germany, 13187 Berlin, Germany, 13439 Collapse <<
NCT00808366	Onychomycosis	Not Applicable	Unknown	October 2009	France ... more >> Hôpital Purpan Recruiting Toulouse, France, 31059 Collapse <<
NCT00781820	Onychomycosis	Phase 3	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2217 mL
- 16.1087 mL
- 32.2174 mL
- 5 mM
- 0.6443 mL
- 3.2217 mL
- 6.4435 mL
- 10 mM
- 0.3222 mL
- 1.6109 mL
- 3.2217 mL

技术信息

CAS号

60628-96-8

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H18N2

运输

蓝冰

分子量

310.39

别名

Bay H-4502;Trifonazole;Mycospor;Amycor;Bifonazol;Bifokey;Bifomyk;Bifon;Canesten brand of bifonazole;Moldina;联苯苄唑

溶解度

DMSO	50.0 mg/mL (161.1 mM) warming
Water	insoluble

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