|(S)-2-(3,5-二羟基苯基)-5-羟基-7-甲氧基苯并二氢吡喃-4-酮|CsnPharm

CAS No.: 118024-26-3

Synonyms: 艾纳香素;蓝光素

Blumeatin is a flavanone found in blumea balsamifera and has been reported to be present in artemisia annua.

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400-920-2911

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400-920-2911

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描述Blumeatin, isolated from Blumea balsamifera DC, could protect liver against injury induced by CCl4 and thioacetamide (TAA). Blu ip inhibited the increase of serum alanine aminotransferase (AAT) and liver triglyceride and increased serum triglyceride, beta-lipoprotein, and liver glycogen content in CCl4-intoxicated rats. Histological lesions of liver were less severe than those of hepatic injury control. Blu ip 0.65 and 3.25 mg/kg inhibited the increase of serum AAT and hepatic TG in thioacetamide (TAA)-intoxicated mice. Blu ip shortened the pentobarbital sleeping time in CCl4-intoxicated mice^[1]. Blumeatin inhibited the growth of SCC-4 oral cancer cells with minimal cytotoxic effects against the normal hTRET-OME cells. The flow cytometric analysis showed that Blumeatin triggers DNA damage in the SCC-4 cells. Blumeatin also activated autophagy in SCC-4 cells which was accompanied with upregulation of LC3B and Beclin 1^[2].
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