|N-(2-(二甲氨基)乙基)-12-氧代-12H-苯并[g]吡啶并[2,1-b]喹唑啉-4-甲酰胺|CsnPharm

CAS No.: 896705-16-1

BMH-21 Catalog No. CSN16976

Synonyms: BMH-21

BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and does not cause phosphorylation of H2AX.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述BMH-21 is a DNA intercalator that binds GC-rich sequences in ribosomal DNA genes and potently represses RNA polymerase I (Pol I) transcription. It inhibited the growth of a wide range of cancer cell lines with a mean GI₅₀ value of 160nM. Incubation of A375 cells with BMH-21 (1μM) for 3 hours potently decreased 5-ethynyl uridine incorporation and repressed the expression of 5′ETS rRNA. BMH-21 demonstrated potent antitumor activity at dosages of 25mg/kg and 50mg/kg in a mouse xenograft model of human melanoma and reduced expression of Ki67. BMH-21 at 50mg/kg also significantly inhibited HCT116 colon cancer tumor growth in vivo^[3].
参考文献

[1] Peltonen K, Colis L, et al. A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell. 2014 Jan 13;25(1):77-90.
[2] Colis L, Ernst G, et al. Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J Med Chem. 2014 Jun 12;57(11):4950-61.
[3] Peltonen K, Colis L, Liu H, Trivedi R, Moubarek MS, Moore HM, Bai B, Rudek MA, Bieberich CJ, Laiho M. A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell. 2014 Jan 13;25(1):77-90.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7746 mL
- 13.8731 mL
- 27.7462 mL
- 5 mM
- 0.5549 mL
- 2.7746 mL
- 5.5492 mL
- 10 mM
- 0.2775 mL
- 1.3873 mL
- 2.7746 mL

技术信息

CAS号

896705-16-1

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H20N4O2

运输

蓝冰

分子量

360.41

别名

BMH-21

溶解度

DMSO	5.0 mg/mL (13.9 mM) warming
Water	Insoluble
Ethanol	2.0 mg/mL (5.5 mM) warming

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

BMH-21 Catalog No. CSN16976

靶点选择性

请登录您的专属账户

确认信息