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CAS No.: 853220-52-7

BML-284 Catalog No. CSN12291

Synonyms: Wnt Agonist I;AMBMP HCl;AMBMP Hydrochloride

BML-284 is a Wnt signaling activator with EC50 value of 0.7 μM for inducing β-catenin and TCF-dependent transcriptional activity.

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The Wnt signaling pathway plays an important role in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation. Many of the key components of the signaling pathway have been elucidated. The Wnt ligand activates downstream signal transduction through interaction with its receptor, Frizzled^[3]. BML-284 induces β‐catenin‐ and TCF‐dependent transcriptional activity in a dose‐dependent manner with an EC₅₀ value of 0.7 μM^[3]. β‐catenin‐ and TCF‐dependent reporter gene expression induced by BML-284 was blocked in the presence of the dominant negative TCF4, thus suggesting that the active compound functions in the canonical Wnt pathway through the TCFs. In a Xenopus model, embryos treated with BML-284 (n=36) had substantial head defects that ranged from significantly diminished heads and complete loss of eyes, to reduced eyes and heads; the posterior structures of tadpoles remained largely intact. These results suggest that the small‐molecule Wnt agonist indeed mimics the effects of Wnt at the whole‐organism level^[3].
参考文献

[1] Wang H, Graves MW 2nd, et al. 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm Res. 2016 Jan;65(1):61-9.
[2] Liu J, Wu X, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90.
[3] Liu J, Wu X, Mitchell B, Kintner C, Ding S, Schultz PG. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90. doi: 10.1002/anie.200462552. PMID: 15724259.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8541 mL
- 14.2706 mL
- 28.5412 mL
- 5 mM
- 0.5708 mL
- 2.8541 mL
- 5.7082 mL
- 10 mM
- 0.2854 mL
- 1.4271 mL
- 2.8541 mL

技术信息

CAS号

853220-52-7

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H18N4O3

运输

蓝冰

分子量

350.37

别名

Wnt Agonist I;AMBMP HCl;AMBMP Hydrochloride;Wnt Agonist

溶解度

DMSO	100.0 mg/mL (285.4 mM)

动物实验配方

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BML-284 Catalog No. CSN12291

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