|N4-(苯并[d][1,3]二氧杂环戊烯-5-基甲基)-6-(3-甲氧基苯基)嘧啶-2,4-二胺盐酸盐|CsnPharm

CAS No.: 2095432-75-8

BML-284 HCl/AMBMP盐酸盐 Catalog No. CSN19238

Synonyms: Wnt Agonist 1;BML 284;CID 11210285

AMBMP HCl is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.

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实验方案

技术信息

生物活性

描述AMBMP HCl is a cell permeable Wnt signaling pathway activator, which induces β-catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 μM.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01358045	Basal Cell Carcinoma	Phase 2	Completed	-	Netherlands ... more >> Maastricht University Medical Center Maastricht, Limburg, Netherlands, 6202 AZ Collapse <<
NCT01878617	Medulloblastoma	Phase 2	Recruiting	December 2026	-
NCT00085202	Brain and Central Nervous Syst... more >>em Tumors Collapse <<	Phase 3	Active, not recruiting	January 2023	United States, North Carolina ... more >> Duke Comprehensive Cancer Center Durham, North Carolina, United States, 27710 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 United States, Texas Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital Houston, Texas, United States, 77030-2399 Australia, New South Wales Sydney Children's Hospital Randwick, New South Wales, Australia, 2031 Children's Hospital at Westmead Westmead, New South Wales, Australia, 2145 Australia, Queensland Lady Cilento Children's Hospital, Brisbane Brisbane, Queensland, Australia, 4029 Australia, Victoria Royal Children's Hospital Parkville, Victoria, Australia, 3052 Canada, Ontario Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Collapse <<

更多
参考文献

[1] Kuncewitch M, Yang WL, et al. WNT Agonist Decreases Tissue Damage and Improves Renal Function After Ischemia-Reperfusion. Shock. 2015 Mar;43(3):268-75.
[2] Liu J, Wu X, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5851 mL
- 12.9256 mL
- 25.8511 mL
- 5 mM
- 0.5170 mL
- 2.5851 mL
- 5.1702 mL
- 10 mM
- 0.2585 mL
- 1.2926 mL
- 2.5851 mL

技术信息

CAS号

2095432-75-8

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H19ClN4O3

运输

蓝冰

分子量

386.83

别名

Wnt Agonist 1;BML 284;CID 11210285;AMBMP hydrochloride

溶解度

DMSO	180.0 mg/mL (465.3 mM)
Water	insoluble

动物实验配方

2% DMSO+40% PEG 300+2% Tween 80+water

9 mg/mL

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01358045	Basal Cell Carcinoma	Phase 2	Completed	-	Netherlands ... more >> Maastricht University Medical Center Maastricht, Limburg, Netherlands, 6202 AZ Collapse <<
NCT01878617	Medulloblastoma	Phase 2	Recruiting	December 2026	-
NCT00085202	Brain and Central Nervous Syst... more >>em Tumors Collapse <<	Phase 3	Active, not recruiting	January 2023	United States, North Carolina ... more >> Duke Comprehensive Cancer Center Durham, North Carolina, United States, 27710 United States, Pennsylvania Children's Hospital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee St. Jude Children's Research Hospital Memphis, Tennessee, United States, 38105 United States, Texas Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital Houston, Texas, United States, 77030-2399 Australia, New South Wales Sydney Children's Hospital Randwick, New South Wales, Australia, 2031 Children's Hospital at Westmead Westmead, New South Wales, Australia, 2145 Australia, Queensland Lady Cilento Children's Hospital, Brisbane Brisbane, Queensland, Australia, 4029 Australia, Victoria Royal Children's Hospital Parkville, Victoria, Australia, 3052 Canada, Ontario Hospital for Sick Children Toronto, Ontario, Canada, M5G 1X8 Collapse <<
NCT00085202	-	-	Active, not recruiting	-	-
NCT02897700	Breast Cancer	Phase 1	Recruiting	December 2020	China, Jiangxi ... more >> Ganzhou City People's Hospital Recruiting Ganzhou, Jiangxi, China, 341000 Contact: Xiao-Ming Zhong, M.D 86-18160779919 jxthrz@qq.com China, Jilin China-Japan Union Hospital, Jilin University Recruiting Changchun, Jilin, China, 130033 Contact: Xian-Ling Cong, M.D 86-0431-89876626 congxl888@hotmail.com China Shanghai 10th People's Hospital, Tongji University School of Medicine Recruiting Shanghai, China, 200072 Contact: Da Fu, Ph.D 86-15921527578 fu800da900@126.com Collapse <<
NCT02724579	Medulloblastoma ... more >> Untreated Childhood Medulloblastoma Collapse <<	Phase 2	Recruiting	May 31, 2025	-
NCT02212574	Medulloblastoma	Not Applicable	Recruiting	May 2022	United States, Arizona ... more >> Phoenix Childrens Hospital Hematology/Oncology Recruiting Phoenix, Arizona, United States, 85016-7710 Contact: Michael Etzl, Dr 602-546-0920 metzl@phoenixchildrens.com United States, Colorado Children's Hospital Colorado Center for Cancer & Blood Disorders Recruiting Aurora, Colorado, United States, 80045 Contact: Kathleen Dorris, M.D., M.S. 720-777-6772 kathleen.dorris@childrenscolorado.org United States, Florida M D Anderson Cancer Center-Orlando Pediatric Hematology/Oncology Not yet recruiting Orlando, Florida, United States, 32806 Contact: Amy Smith, Dr 321-841-8588 amy.smith@orlandohealth.com All Children's Hospital Pediatric Hematology/Oncology Recruiting Saint Petersburg, Florida, United States, 33701 Contact: Stacie Stapleton, Dr 727-767-4176 Stacie.Stapleton@allkids.org United States, Georgia Children's Healthcare of Atlanta- Egleston Pediatric Neuro-Oncology Recruiting Atlanta, Georgia, United States, 30322 Contact: Tobey MacDonald, Dr 404-727-1447 tobey.macdonald@emory.edu United States, Illinois Ann and Robert H Lurie Children's Hospital of Chicago Hematology/Oncology Recruiting Chicago, Illinois, United States, 60611 Contact: Stewart Goldman, Dr 312-227-4844 sgoldman@northwestern.edu United States, Maryland Johns Hopkins University Recruiting Baltimore, Maryland, United States, 21287 Contact: Kenneth Cohen, MD, MBA 410-614-5055 kcohen@jhmi.edu Contact: Tammy Scott, RN 4140-614-5990 scottta@jhmi.edu United States, Massachusetts Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Pratiti Bandopadhayay, MBBS, PhD United States, Missouri Washington University School of Medicine Pediatric Hematology/Oncology Recruiting Saint Louis, Missouri, United States, 63110 Contact: Joshua Rubin, Dr 314-454-6018 rubin_j@kids.wustl.edu United States, New Jersey Hackensack University Medical Center Recruiting Hackensack, New Jersey, United States, 07601 Contact: Derek Hanson, MD 551-996-5437 dhanson@hackensackumc.org United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Kevin De Braganca, MD 212-639-3449 debragak@mskcc.org United States, North Carolina Duke University Medical Center Recruiting Durham, North Carolina, United States, 27705 Contact: David Ashley, MD, PhD david.ashley@duke.edu Principal Investigator: David Ashley, MD, PhD United States, Ohio Nationwide Children's Hospital Recruiting Columbus, Ohio, United States, 43205 Contact: Mohamed S AbdelBaki, MBBCh 614-722-3250 mohamed.abdelbaki@nationwidechildrens.org United States, Oregon Oregon Health and Science University Pediatric Hematology/Oncology Not yet recruiting Portland, Oregon, United States, 97239-3098 Contact: Kellie Nazemi, Dr 503-494-0714 nazemik@ohsu.edu United States, Washington Seattle Children's Hospital Hematology/Oncology Recruiting Seattle, Washington, United States, 98105 Contact: Sarah Leary, Dr 206-987-2106 sarah.leary@seattlechildrens.org United States, Wisconsin Childrens Hospital of Wisconsin (Medical College of Wisconsin) Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Jeffrey Knipstein, MD 414-955-4108 jknipstein@jhmi.edu Collapse <<
NCT03315702	-	-	Active, not recruiting	October 31, 2017	China, Shanghai ... more >> Department of Anesthesia, Shanghai Xinhua hospital Shanghai, Shanghai, China, 200082 Collapse <<

BML-284 HCl/AMBMP盐酸盐 Catalog No. CSN19238

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