|(4-丁氧基-1H-吡唑并[3,4-b]吡啶-5-基)(2,6-二氟-4-甲基苯基)甲酮|CsnPharm

CAS No.: 582315-72-8

BMS-265246 Catalog No. CSN16547

Synonyms: BMS-265246

BMS-265246 is a potent and selective CDK1/2 inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 and 9 nM respectively.

规格	价格	促销价格	库存	数量

400-920-2911

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tech@csnpharm.cn

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 CDK1

IC50:6nM CDK2/cyclin E

IC50:9nM
描述Cyclin-dependent kinases (CDKs) are a family of protein kinases which along with their regulatory subunit cyclins play a key role in the growth, development, proliferation and death of eukaryotic cells and are responsible for insuring integrity in the coordination of events through the cell cycle^[3]. BMS-265246 has been identified as a potent, selective inhibitor of CDK1 (IC₅₀ = 0.006 μM) and CDK2 (IC₅₀ = 0.009 μM) in vitro. In an ovarian cancer cell line (A2780) inhibitor BMS-265246 produced a cytotoxic effect with an IC₅₀ = 0.76 μM^[3].
参考文献

[1] Sutherland JJ, Low J, Blosser W, Dowless M, Engler TA, Stancato LF. A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. Mol Cancer Ther. 2011 Feb;10(2):242-54.
[2] Misra RN, Xiao Hy, et al. 1H-Pyrazolo[3,4-b] pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2405-8.
[3] Misra RN, Xiao Hy, Rawlins DB, Shan W, Kellar KA, Mulheron JG, Sack JS, Tokarski JS, Kimball SD, Webster KR. 1H-Pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-Difluorophenacyl analogues. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2405-8. doi: 10.1016/s0960-894x(03)00381-0. PMID: 12824044.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8957 mL
- 14.4783 mL
- 28.9567 mL
- 5 mM
- 0.5791 mL
- 2.8957 mL
- 5.7913 mL
- 10 mM
- 0.2896 mL
- 1.4478 mL
- 2.8957 mL

技术信息

CAS号

582315-72-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H17F2N3O2

运输

蓝冰

分子量

345.34

别名

BMS-265246

溶解度

DMSO	20.0 mg/mL (57.9 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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靶点	Description	IC50
CDK1		IC50:6nM
CDK2/cyclin E		IC50:9nM

BMS-265246 Catalog No. CSN16547

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