|2-((3-((2-(4-氯苯基)-5-甲基恶唑-4-基)甲氧基)苄基)(甲氧基羰基)氨基)乙酸|CsnPharm

CAS No.: 1000998-59-3

BMS-687453 Catalog No. CSN17378

Synonyms: Bms-687453

BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.

规格	价格	促销价格	库存	数量

400-920-2911

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技术信息

生物活性

描述BMS-687453 is a potent and selective PPARα agonist, with an EC50 of 10 nM for human PPARα and 410-fold selectivity vs human PPARγ in PPAR-GAL4 transactivation assays.
参考文献

[1] Li J, Kennedy LJ, et al. Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4 yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). J Med Chem. 2010 Apr 8;53(7):2854-64.
[2] Mukherjee R, Locke KT, et al. Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. J Pharmacol Exp Ther. 2008 Dec;327(3):716-26.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2479 mL
- 11.2394 mL
- 22.4787 mL
- 5 mM
- 0.4496 mL
- 2.2479 mL
- 4.4957 mL
- 10 mM
- 0.2248 mL
- 1.1239 mL
- 2.2479 mL

技术信息

CAS号

1000998-59-3

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H21ClN2O6

运输

蓝冰

分子量

444.87

别名

Bms-687453

溶解度

DMSO	89.0 mg/mL (200.1 mM)
Water	Insoluble
Ethanol	89.0 mg/mL (200.1 mM)

动物实验配方

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