|BMY7378二盐酸盐|CsnPharm

CAS No.: 21102-95-4

BMY 7378/BMY 7378 二盐酸盐 Catalog No. CSN13005

BMY 7378 2HCl is a 5-HT1A partial agonist and a high-affinity α1D adrenoceptor antagonist with Ki values of 2, 800 and 600 nM for cloned rat α1D, rat α1A and hamster α1B receptors respectively.

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400-920-2911

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技术信息

生物活性

描述BMY 7378 Dihydrochloride is a multi-target inhibitor, which acts on α 2C and α 1D adrenoceptors, with PKI of 6.54 and 8.2, respectively. It is a mixed 5-HT1A receptor agonist and antagonist, with PKI of 8.3^[3]. In vitro research suggests that BMY 7378 Dihydrochloride has a PKI value 6.06±0.09 in AC01 cells^[4]. In vivo , BMY 7378 Dihydrochloride dose-dependently (0.25-5 mg/kg) decreased 8-OH-DPAT (0.75 mg/kg)-induced unmeasured level of forepaw stampede and head shaking in rats. In the ventral hippocampus of anesthetized rats, BMY 7378 Dihydrochloride significantly reduced the release of 5-HT in a dose-dependent manner by microdialysis^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1814 mL
- 10.9070 mL
- 21.8140 mL
- 5 mM
- 0.4363 mL
- 2.1814 mL
- 4.3628 mL
- 10 mM
- 0.2181 mL
- 1.0907 mL
- 2.1814 mL

技术信息

CAS号

21102-95-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H33Cl2N3O3

运输

蓝冰

分子量

458.42

别名

溶解度

DMSO	67.0 mg/mL (146.2 mM)
Water	115.0 mg/mL (250.9 mM)

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BMY 7378/BMY 7378 二盐酸盐 Catalog No. CSN13005

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