|1-([1,1'-联苯]-3-基)-4-氨基-5-氯嘧啶-2(1H)-酮|CsnPharm

CAS No.: 2280037-51-4

Bobcat339 Catalog No. CSN24474

Synonyms: BC339

Bobcat339 is a TET inhibitor with IC50 values of 33μM and 73μM for TET1 and TET2, respectively.

规格	价格	促销价格	库存	数量

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实验方案

技术信息

生物活性

描述The TET (Ten-11 translocation methylcytosine dioxygenase) family of enzymes is known to be responsible for catalyzing the reverse process that is DNA demethylation by recognizing 5-methylcytosine and oxidizing the methyl group via an Fe(II)/alpha-ketoglutarate-dependent mechanism. Bobcat339 is a selective cytosine based TET enzyme inhibitor with IC₅₀ values of 33 μM and 73 μM, respectively, for TET1 and TET2. HT-22 cells, an immortalized mouse hippocampal neuronal cell line, treated with 10 μM Bobcat339 for 24 h had significantly reduced global 5hmC levels as compared to the vehicle control, demonstrating its ability to reduce DNA 5hmC abundance by inhibiting TET enzyme function in living cells and providing support for its utility as a viable pharmacological probe^[1].
参考文献

[1] Chua GNL, Wassarman KL, Sun H, et al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019;10(2):180-185

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3586 mL
- 16.7932 mL
- 33.5864 mL
- 5 mM
- 0.6717 mL
- 3.3586 mL
- 6.7173 mL
- 10 mM
- 0.3359 mL
- 1.6793 mL
- 3.3586 mL

技术信息

CAS号

2280037-51-4

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H12ClN3O

运输

蓝冰

分子量

297.74

别名

BC339

溶解度

DMSO	60.0 mg/mL (201.5 mM)
Water	insoluble

动物实验配方

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