|bpV (HOpic)(钾盐)|CsnPharm

CAS No.: 722494-26-0

BpV(HOpic) Catalog No. CSN21090

Synonyms: Bisperoxovanadium(HOpic);bpV(HOpic) (potassium salt)

bpV(HOpic) shows selective inhitory effect on PTP and PTEN (IC50 = 14 nM) and acts as an insulin mimic. It also can prevent myocardial ischemia-reperfusion injury by enhancing PI3K/Akt signaling.

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实验方案

技术信息

生物活性

描述The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that inhibit cell survival and proliferation by inactivating PI 3-kinase-dependent signaling pathway. bpV (HOpic) is a vanadate derivative that inhibits PTEN with an IC50 value of 14 nM. In primary cardiomyocytes incubated with bpV (HOpic) without the exposure to simulated ischemia-reperfusion (SIR) for 2 hours, bpV (HOpic) at 10, 15, and 20 μM decreased the percentage of trypan-positive cells compared with non-bpV-treated cells. The maximal effect of bpV (HOpic) on the suppression of cell death was achieved at 15 μM. The cell viability as measured by MTT assay was significantly improved by bpV (HOpic) at 5 – 20 μM in cells with or without SIR. The effect of bpV (HOpic) on cardiomyocytes apoptosis was determined by TUNEL assay, in which bpV (HOpic) at 10, 15, and 20 μM decreased apoptosis in cells without SIR, whereas the anti-apoptotic effect of bpV (HOpic) in cells exposed to SIR was observed at 5, 10, and 15 μM. In rats received bpV (HOpic) before I^30m and R^4h, the myocardial infarct size was reduced compared to control group, and the maximal effect of bpV (HOpic) was achieved at 1.0 mg/kg. However, the protective effect of bpV (HOpic) on reducing myocardial infarct size was abrogated by wortmannin and L-NAME. In rats treated with bpV (HOpic) (1.0 mg/kg) either before ischemia (BpV-BI) or before reperfusion (BpV-BR), bpV (HOpic) reduced the increase of the left ventricular internal diameter in diastole and in systole after the I/R injury. In rats received 1.0 mg/kg bpV (HOpic) one hour before ischemia, the PTEN activity was significantly reduced at 30 m of ischemia and 4 and 12h of reperfusion.
作用机制bpV (HOpic) acts a PTEN inhibitor by interacting with the active center of PTEN, the CX5R motif.
动物研究
剂量
Rat: 0.05 mg/kg^[1] (i.p.)

给药途径
i.p.
临床研究

动物研究
剂量	Rat: 0.05 mg/kg^[1] (i.p.)
给药途径	i.p.

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02496598	Primary Ovarian Insufficiency ... more >> Infertility Collapse <<	Not Applicable	Terminated(Results were not pr... more >>omising) Collapse <<	-	United States, Colorado ... more >> Fertility Laboratories of Colorado Lone Tree, Colorado, United States, 80124 National Foundation for Fertility Research Lone Tree, Colorado, United States, 80124 Collapse <<

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8799 mL
- 14.3994 mL
- 28.7989 mL
- 5 mM
- 0.5760 mL
- 2.8799 mL
- 5.7598 mL
- 10 mM
- 0.2880 mL
- 1.4399 mL
- 2.8799 mL

技术信息

CAS号

722494-26-0

储存条件

粉末: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H4K2NO8V

运输

蓝冰

分子量

347.24

别名

Bisperoxovanadium(HOpic);bpV(HOpic) (potassium salt)

溶解度

DMSO	insoluble
Water	150.0 mg/mL (432.0 mM) warming

动物实验配方

0.5% CMC-Na

46 mg/mL

clear

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BpV(HOpic) Catalog No. CSN21090

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