1374601-41-8|BRD9539|CsnPharm

CAS No.: 1374601-41-8

BRD9539 Catalog No. CSN18961

Synonyms: BRD9539

BRD9539 inhibits G9a activity with an IC50 of 6.3 μM, inhibits PRC2 activity with a similar IC50.

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400-920-2911

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tech@csnpharm.cn

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400-920-2911

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生物活性

实验方案

技术信息

生物活性

描述The methylation of lysine 9 on histone H3 by the histone methyltransferase G9a is a modification related to aberrant silencing of tumor suppressor genes. BRD9539 is the potential active form of BRD4770, a histone methyltransferase inhibitor in cells. BRD9539 dose-dependently inhibited G9a activity with an IC50 value of 6.3μM, but its inhibitory effect decreased with increasing S-adenosylmethionine concentrations. BRD9539 also blocked PRC2 activity with a similar IC50 value but had no inhibitory effect against SUV39H1 or DNMT1 up to 40μM. BRD9539 showed no activity in cell-based assays, probably due to impaired cell permeability. BRD9539 at 5 or 10μM exhibited no inhibitory activity towards 100 kinases related to cell-cycle regulation and cancer cell biology, and 16 other chromatin-modifying enzymes^[1].

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5035 mL
- 12.5175 mL
- 25.0349 mL
- 5 mM
- 0.5007 mL
- 2.5035 mL
- 5.0070 mL
- 10 mM
- 0.2503 mL
- 1.2517 mL
- 2.5035 mL

技术信息

CAS号

1374601-41-8

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H21N3O3

运输

蓝冰

分子量

399.44

别名

BRD9539

溶解度

DMSO	62.5 mg/mL (156.5 mM)
Water	insoluble

动物实验配方

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