CAS No.: 59803-98-4
Brimonidine/溴莫尼定 Catalog No. CSN10049
Synonyms: UK 14304;AGN190342;Alphagan P
UK-14304 is an adrenergic receptor α2 agonist which can activate ERK in epicardial coronary artery culture, inhibit R-type calcium currents, as well as inhibit hormone-sensitive lipase activity and suppresses lipogenesis in adipose tissue.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Chopin P, Colpaert FC, Marien M. Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther. 1999 Feb;288(2):798-804.
- [2] Cambridge D. UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol. 1981 Jul 10;72(4):413-5.
- [3] Andorn AC, Carlson MA, Gilkeson RC. Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci. 1988;43(22):1805-1812.
- [4] Chopin P, Colpaert FC, Marien M. Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther. 1999;288(2):798-804.
- [5] Hernández-Hernández E, Miralles A, Esteban S, García-Fuster MJ. Repeated treatment with the α2-adrenoceptor agonist UK-14304 improves cognitive performance in middle-age rats: Role of hippocampal Fas-associated death domain. J Psychopharmacol. 2018;32(2):248-255.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 59803-98-4 | 储存条件 |
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| 分子式 | C11H10BrN5 | 运输 | 蓝冰 | |||
| 分子量 | 292.13 | 别名 | UK 14304;AGN190342;Alphagan P;溴莫尼定 | |||
| 溶解度 |
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动物实验配方 |
