生物活性

• 描述Bromfenac Sodium is a brominated NSAID (nonsteroidal anti-inflammatory drugs) with strong in vitro anti-inflammatory potency. In rat models of acute (carrageenan paw edema) and chronic (adjuvant arthritis) inflammation, preparations of bromfenac at concentrations as low as 0.01-0.32% (0.01-0.32 mg bromfenac) produced significant anti-inflammatory activity when applied to the injected paw or to the backs of rats, and the same dose showed topical analgesic activity in the acetylcholine-induced abdominal constriction test in mice^[3]. Bromfenac protects against TGF-β1-induced synthesis of fibronectin, α-SMA, and collagen III in human pterygium fibroblasts and primary human conjunctival fibroblasts at least in part by inactivating the AKT and ERK pathways^[4]. Bromfenac was well tolerated when given alone or in combination with intravitreal anti-vascular endothelial growth factor agents, topical corticosteroids, or topical mast-cell stabilizers. The most common adverse event reported was ocular irritation^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01097447	-	-	Terminated(Terminated to initi... more >>ate FDA IND-cleared study protocol) Collapse <<	-	United States, California ... more >> Clear View Eye & Laser Medical Center San Diego, California, United States, 92121 United States, Colorado Corneal Consultants of Colorado, P.C Littleton, Colorado, United States United States, Illinois Chicago Cornea Consultants, LTD Hoffman Estates, Illinois, United States United States, Minnesota Minnesota Eye Consultants, P.A. Bloomington, Minnesota, United States, 55431 United States, Texas Cornea Associates of Texas Dallas, Texas, United States, 75231 Collapse <<
  NCT01657266	Cataract Phac... more >>oemulsification Cataract Surgery Collapse <<	Phase 2	Completed	-	Mexico ... more >> Hospital Civil de Guadalajara Fray Antonio Alcalde Guadalajara, Jalisco, Mexico, 44280 Collapse <<
  NCT02973880	Cataract Extraction ... more >> Cataract Collapse <<	Phase 3	Not yet recruiting	September 2017	Germany ... more >> Klinikum Ernst von Bergmann Ophthalmologie Not yet recruiting Potsdam, Germany, 14467 Contact: Anja Liekfeld, MD, Prof.    00493312415101    aliekfeld@klinikumevb.de    Contact: Silvia Zarmas-Roehl, MD    00491739596666    szarmas@klinikumevb.de    Principal Investigator: Anja Liekfeld, MD, Prof.          Sub-Investigator: Silvia Zarmas-Roehl, MD          Augenklinik und Poliklinik Ophthalmologie Not yet recruiting Wurzburg, Germany, 87080 Contact: Thomas Ach, MD    004993120120458    ach_t@ukw.de    Contact: Daniel Kampik, MD    004993120120627    kampik_d@ukw.de    Principal Investigator: Thomas Ach, MD          Sub-Investigator: Daniel Kampik, MD          Italy Azienda Ospedaliero-Universitaria Careggi Not yet recruiting Firenze, Italy, 50134 Contact: Rita Mencucci, MD    0039055411765    rita.mencucci@unifi.it    Contact: Eleonora Favuzza, MD    00393288151559    elefavuzza@virgilio.it    Principal Investigator: Rita Mencucci, MD          Sub-Investigator: Eleonora Favuzza, MD          Azienda Ospedaliera Fatebenefratelli e Oftalmico Not yet recruiting Milano, Italy, 20121 Contact: Antonio Scialdone, MD, Prof.    00390263632754    antonio.scialdone@asst-fbf-sacco.it    Contact: Francesco De Gaetano, MD    00393397147220    fradega1975@yahoo.it    Principal Investigator: Antonio Scialdone, MD, Prof.          Sub-Investigator: Francesco De Gaetano, MD          Policlinico Universitario A. Gemelli Not yet recruiting Roma, Italy, 00168 Contact: Aldo Caporossi, MD, Prof.    00390630155228    aldo.caporossi@unicatt.it    Contact: Antonio Villano, MD    00393392410616    antonio.villano.md@gmail.com    Principal Investigator: Aldo Caporossi, MD, Prof.          Sub-Investigator: Antonio Villano, MD          Romania Centrul Medical Unirea Not yet recruiting Bucuresti, Romania, 010576 Contact: Sinziana Gradinaru, MD    00407256535515    sinziana.gradinaru@reginamaria.ro    Contact: Ruxandra Tudosescu, MD          Principal Investigator: Sinziana Gradinaru, MD          Sub-Investigator: Ruxandra Tudosescu, MD          Spitalul Universitar de Urgenta Bucuresti Not yet recruiting Bucuresti, Romania, 050098 Contact: Liliana Voinea, MD, Prof.    0040785205632    voineamliliana@yahoo.com    Contact: Radu Ciuluvica, MD          Principal Investigator: Liliana Voinea, MD, Prof.          Sub-Investigator: Radu Ciuluvica, MD          Spitalul Universitar de Urgenta Bucuresti Not yet recruiting Bucuresti, Romania, 050098 Contact: Alina P Cherecheanu, MD    0040723507047    alina_cherecheanu@yahoo.com    Contact: Aurelian M Ghita, MD          Principal Investigator: Alina P Cherecheanu, MD          Sub-Investigator: Aurelian M Ghita, MD Collapse <<

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• 参考文献

• [1] Kirkman SK, Zhang MY, et al. Isolation and identification of bromfenac glucoside from rat bile. Drug Metab Dispos. 1998 Jul;26(7):720-3.

  [2] Sancilio LF, Nolan JC, et al. The analgesic and antiinflammatory activity and pharmacologic properties of bromfenac. Arzneimittelforschung. 1987 May;37(5):513-9.

  [3] Nolan JC, Wagner LE, Gathright CE, Stephens DJ, Sancilio LF. The topical anti-inflammatory and analgesic properties of bromfenac in rodents. Agents Actions. 1988 Aug;25(1-2):77-85

  [4] Chen K, Lai K, Zhang X, Qin Z, Fu Q, Luo C, Jin X, Hu J, Liu S, Yao K. Bromfenac Inhibits TGF-β1-Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1156-1164

  [5] Schechter BA. Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies. Clin Ophthalmol. 2019 Aug 1;13:1439-1460

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