CAS No.: 21499-66-1
Bruceine D/鸦胆子苦素D Catalog No. CSN13458
Synonyms: 鸦胆子苦素D
Bruceine D, a natural product isolated and purified from the barks of Ailanthus altissima, may have the potential to be used as a natural viricide, or a lead compound for viricides, inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW1990 and CAPAN-1, and induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Liu L, Lin ZX, et al. Involvement of the mitochondrial pathway in bruceine D-induced apoptosis in Capan-2 human pancreatic adenocarcinoma cells. Int J Mol Med. 2012 Jul;30(1):93-9.
- [2] Wang Y, Wu ZF, et al. In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Vet Parasitol. 2011 Apr 19;177(1-2):127-33.
- [3] Mao G, Tian Y, Sun Z, Ou J, Xu H. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019;67(15):4232-4239
- [4] Cheng Z, Yuan X, Qu Y, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017;403:195-205
- [5] Zhang JY, Lin MT, Tung HY, et al. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway. Am J Cancer Res. 2016;6(4):819-826. Published 2016 Mar 15
- [6] Xie JH, Lai ZQ, Zheng XH, et al. Apoptosis induced by bruceine D in human non‑small‑cell lung cancer cells involves mitochondrial ROS‑mediated death signaling. Int J Mol Med. 2019;44(6):2015-2026
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 21499-66-1 | 储存条件 |
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| 分子式 | C20H26O9 | 运输 | 蓝冰 | |||
| 分子量 | 410.42 | 别名 | 鸦胆子苦素D | |||
| 溶解度 |
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动物实验配方 |
