CAS No.: 924537-98-4
BT-13 Catalog No. CSN28779
Synonyms: BT-13
BT13 acts as direct RetA agonists and interacts with GFRα1 at the allosteric site in GDNF-GFRα1-RetA complex. It was similar to NGF and ARTN in selectively promoting neurite outgrowth from the peptidergic class of adult sensory neurons in culture, but was opposite to ARTN in causing neurite elongation without affecting initiation.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 参考文献
- [1] Ivanova L, Tammiku-Taul J, García-Sosa AT, Sidorova Y, Saarma M, Karelson M. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-Derived Neurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414. doi: 10.1021/acsomega.8b01524. Epub 2018 Sep 19. PMID: 30320260; PMCID: PMC6173496.
- [2] Sidorova YA, Bespalov MM, Wong AW, Kambur O, Jokinen V, Lilius TO, Suleymanova I, Karelson G, Rauhala PV, Karelson M, Osborne PB, Keast JR, Kalso EA, Saarma M. A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat. Front Pharmacol. 2017 Jun 21;8:365. doi: 10.3389/fphar.2017.00365. PMID: 28680400; PMCID: PMC5478727.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 924537-98-4 | 储存条件 |
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| 分子式 | C23H27F4N3O4S | 运输 | 蓝冰 | |
| 分子量 | 517.54 | 别名 | BT-13 |
