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CAS No.: 2438-72-4

Bufexamac/丁苯羟酸 Catalog No. CSN10503

Synonyms: Bufexamic acid;CP-1044-J-3;Droxaryl

Bufexamac is a COX inhibitor used as an anti-inflammatory agent.

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实验方案

技术信息

生物活性

描述Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent^[3]. Bufexamac is a drug widely used as an anti-inflammatory agent on the skin. Bufexamac was capable of specifically inhibiting LTA4H enzymatic activity and revealed the mode of interaction of bufexamac and LTA4H (a hydrolysis product of epoxide leukotriene A4) using X-ray crystallography. Moreover, bufexamac significantly prevented the production of LTB4 (Leukotriene B4) in neutrophil and inhibited the fMLP-induced neutrophil migration through inhibition of LTA4H. Finally, bufexamac significantly attenuated lung inflammation as reflected by reduced LTB4 levels and weakened neutrophil infiltration in bronchoalveolar lavage fluid from a lipopolysaccharide-induced ALI (acute lung injury) mouse model^[4].
参考文献

[1] Bantscheff M, Hopf C, et al. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011 Mar;29(3):255-65.
[2] Kranke B, Szolar-Platzer C, et al. Epidemiological significance of bufexamac as a frequent and relevant contact sensitizer. Contact Dermatitis. 1997 Apr;36(4):212-5.
[3] Bantscheff M, Hopf C, Savitski MM, et al. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011;29(3):255-265
[4] Xiao Q, Dong N, Yao X, et al. Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H. Sci Rep. 2016;6:25298. Published 2016 Apr 29

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.4789 mL
- 22.3946 mL
- 44.7892 mL
- 5 mM
- 0.8958 mL
- 4.4789 mL
- 8.9578 mL
- 10 mM
- 0.4479 mL
- 2.2395 mL
- 4.4789 mL

技术信息

CAS号

2438-72-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H17NO3

运输

蓝冰

分子量

223.27

别名

Bufexamic acid;CP-1044-J-3;Droxaryl;Parfenac;丁苯羟酸

溶解度

DMSO	200.0 mg/mL (895.8 mM)
Water	insoluble

动物实验配方

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