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CAS No.: 477775-14-7

Buloxibutid Catalog No. CSN20314

Synonyms: AT2 Agonist C21;Compound 21;M24

AT2R agonist C21 is a small-molecule ATR receptor (AT2R) agonist.

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生物活性

描述AT2R Agonist C21 is an angiotensin II type 2 receptor agonist. Compound 21 (0.12 mg/kg/day for 4 weeks, p.o.) treatment improved fine motor skills after MCAO (middle cerebral artery occlusion) through modulation of the microglia/macrophage inflammatory properties. In addition, C21 increased M2 polarization and reduced the M1:M2 ratio in vitro. Thus, delayed administration of C21 downregulates post-stroke inflammation in female diabetic animals^[3]. AT2R agonist C21 effectively prevents the development of PSCI in aged animals^[4]. The administration of C21 (0.1-10 μM/15 min) increased the surface levels of TRKB (tropomyosin-related kinase B receptors) but was not sufficient to increase the levels of phosphorylated TRKB (pTRKB) in cultured cortical neurons from rat embryos. Consistent with increased TRKB surface expression, C21 (10 μM/15 min or 3 days) facilitated the effect of BDNF (0.1 ng/mL/15 min) on pTRKB in these cells^[5]. In cultured human RPE cells, activation of AT2R with C21 significantly blocked Angiotensin II, LPS and hydrogen peroxide -induced NF-κB activation and inflammatory cytokine expression^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1025 mL
- 10.5125 mL
- 21.0250 mL
- 5 mM
- 0.4205 mL
- 2.1025 mL
- 4.2050 mL
- 10 mM
- 0.2103 mL
- 1.0513 mL
- 2.1025 mL

技术信息

CAS号

477775-14-7

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H29N3O4S2

运输

蓝冰

分子量

475.62

别名

AT2 Agonist C21;Compound 21;M24;M-024;C-21

溶解度

DMSO	5.0 mg/mL (10.5 mM) warming

动物实验配方

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总药量计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 动物数量只每天给药次给药天

需要的总药量：mg

工作液计算器 ✕

动物实验：给药剂量mg/kg 动物体重g 给药体积μL

您需要配制的工作液浓度为：mg/mL

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