CAS No.: 1312445-63-8
Buparlisib HCl/NVP-BKM120盐酸盐 Catalog No. CSN13693
Synonyms: BKM120 Hydrochloride;NVP-BKM120 Hydrochloride;BKM120 HClBuparlisib HCl
NVP-BKM120 Hcl(BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ.
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纯度 & 质量文件
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靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01971489 Adult Solid Neoplasm ... more >> Recurrent Non-Small Cell Lung Carcinoma Stage IIIA Non-Small Cell Lung Cancer Stage IIIB Non-Small Cell Lung Cancer Stage IV Non-Small Cell Lung Cancer Collapse << Phase 1 Withdrawn - United States, New York ... more >> Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Collapse << NCT01487265 Non Small Cell Lung Cancer Phase 2 Active, not recruiting December 2017 United States, Florida ... more >> Florida Cancer Specialists South Fort Myers, Florida, United States, 33916 Florida Hospital Cancer Institute Orlando, Florida, United States, 32804 Florida Cancer Specialists North Saint Petersburg, Florida, United States, 33705 Florida Cancer Specialists East West Palm Beach, Florida, United States, 33401 United States, Ohio Oncology Hematology Care, Inc. Cincinnati, Ohio, United States, 45242 United States, Tennessee Tennessee Oncology, PLLC Nashville, Tennessee, United States, 37023 United States, Texas Center for Cancer and Blood Disorders Fort Worth, Texas, United States, 76104 Collapse << NCT01487265 - - Active, not recruiting - -
实验方案
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技术信息
| CAS号 | 1312445-63-8 | 储存条件 |
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| 分子式 | C18H22ClF3N6O2 | 运输 | 蓝冰 | |
| 分子量 | 446.85 | 别名 | BKM120 Hydrochloride;NVP-BKM120 Hydrochloride;BKM120 HClBuparlisib HCl;Buparlisib hydrochloride;BKM120-AAA ;Buparlisib HCl |
