生物活性

• 描述Butenafine (Hydrochloride), a derivative of benzylamine with potent fungicidal activity, is a new generation of antimycotic compound that has shown to be extremely effective against experimentally-induced tinea pedis in the guinea-pig, a situation that resembles synergetic pathology similar to that of tinea pedis in humans^[3]. Butenafine HCl showing activity against beta-hemolytic Streptococcus Group A and Corynebacterium only^[1]. In vitro, the minimum concentration that completely inhibited growth of dermatophytes (MIC) and the minimum fungicidal concentrations (MFC) for butenafine against T. mentagrophytes and M. canis were similar (0.012 to 0.05 mg/L) and were 4 to 130 times lower than those for naftifine, tolnaftate, clotrimazole and bifonazole^[4].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01119742	Interdigital Tinea Pedis	Phase 1	Terminated(Insufficient number... more >> of baseline eligible patient) Collapse <<	-	-
  NCT00835510	Tinea Pedis	Phase 1	Completed	-	United States, California ... more >> Investigator Site Burbank, California, United States Investigator Site San Diego, California, United States United States, Florida Investigator Site Miami, Florida, United States United States, Georgia Investigator Site Martinez, Georgia, United States Investigator Site Stockbridge, Georgia, United States United States, Michigan Investigator Site Clinton Township, Michigan, United States United States, North Carolina Investigator Site Hickory, North Carolina, United States Investigator Site Raleigh, North Carolina, United States Investigator Site Salisbury, North Carolina, United States United States, Ohio Investigator Site Sylvania, Ohio, United States United States, South Carolina Investigator Site Simpsonville, South Carolina, United States United States, Tennessee Investigator Site Bristol, Tennessee, United States Investigator Site Nashville, Tennessee, United States United States, Texas Investigator Site College Station, Texas, United States Investigator Site Houston, Texas, United States Investigator Site San Antonio, Texas, United States Belize Investigator Site Belize City, Belize Collapse <<
  NCT01580878	Tinea Pedis	Phase 1	Completed	-	-

• 更多
• 参考文献

• [1] Kokjohn K, Bradley M, Griffiths B, Ghannoum M. Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. Int J Dermatol. 2003;42 Suppl 1:11‐17

  [2] Arika T, Yokoo M, et al, Yamaguchi H. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. Antimicrob Agents Chemother. 1990 Nov;34(11):2250-3.

  [3] Syed TA, Maibach HI. Butenafine hydrochloride: for the treatment of interdigital tinea pedis. Expert Opin Pharmacother. 2000;1(3):467‐473

  [4] McNeely W, Spencer CM. Butenafine. Drugs. 1998;55(3):405‐413